Alteration of peripheral CD4+CD(25+ regulatory T lymphocytes in pregnancy and pre-eclampsia.

Alteration of peripheral CD4+CD(25+ regulatory T lymphocytes in pregnancy and pre-eclampsia. Research Abstract Details 

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Alteration of peripheral CD4+CD(25+ regulatory T lymphocytes in pregnancy and pre-eclampsia. Abstract Text:

Dongxiao Hu,Yan Chen,Wuwen Zhang,Hanzhi Wang,Zhengping Wang,Minyue Dong,

OBJECTIVES: To clarify the change of peripheral CD4+CD25+ regulatory T lymphocytes in normal pregnancy and pre-eclampsia and to explore its role in the pathogenesis of pre-eclampsia. METHODS: Twenty-seven women with pre-eclampsia, 27 with normal third trimester pregnancy and 27 healthy non-pregnant women were recruited. Blood samples were taken and surface antigen CD4 and CD25 were labelled with fluorescence-conjugated antibodies. CD4+CD25+ regulatory T cells were analysed by flow cytometry, and the proportion in T cells and the amount of regulatory T lymphocytes were calculated. RESULTS: The amount and the proportion of regulatory T cells were not significantly different among non-pregnant, normal pregnancy and pre-eclampsia groups (p>0.05 for both). There were no significant differences in the proportion and the amount of CD4+CD25+ regulatory T cells between mild and severe pre-eclampsia subgroups (p>0.05 for both). CONCLUSIONS: No significant change of peripheral regulatory T cells was observed in the current investigation, suggesting other mechanisms rather than CD4+CD25+ regulatory T cells were involved in the pathogenesis of pre-eclampsia.

Alteration of peripheral CD4+CD(25+ regulatory T lymphocytes in pregnancy and pre-eclampsia. Publishing Authors By Initials

D Hu,Y Chen,W Zhang,H Wang,Z Wang,M Dong,

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Alteration of peripheral CD4+CD(25+ regulatory T lymphocytes in pregnancy and pre-eclampsia. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Acta obstetricia et gynecologica Scandinavica

VOLUME: 87

Page Numbers: 190-4

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ISSN: 1600-0412

DAY: 30

MONTH: 01

YEAR: 2008

Alteration of peripheral CD4+CD(25+ regulatory T lymphocytes in pregnancy and pre-eclampsia. Information

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LANGUAGE: eng

NlmUniqueID: 370343

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Grant and Affiliation Information for Alteration of peripheral CD4+CD(25+ regulatory T lymphocytes in pregnancy and pre-eclampsia.

AFFILIATION: Women's Hospital, School of Medicine, Zhejiang University, Hangzhou, China.

Country: Denmark

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MEDLINETA: Acta Obstet Gynecol Scand

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