Alteration of brain metabolites in young alcoholics without structural changes.

Alteration of brain metabolites in young alcoholics without structural changes. Research Abstract Details 

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Alteration of brain metabolites in young alcoholics without structural changes. Abstract Text:

Eun Lee,Dong-Pyo Jang,Jae-Jin Kim,Suk Kyoon An,Sangjin Park,In-Young Kim,Sun I Kim,Kang-Jun Yoon,Kee Namkoong,Eun Lee,Dong-Pyo Jang,Jae-Jin Kim,Suk Kyoon An,Sangjin Park,In-Young Kim,Sun I Kim,Kang-Jun Yoon,Kee Namkoong,

Using proton magnetic resonance spectroscopy and magnetic resonance imaging, we investigated concentrations of various brain metabolites, including glutamate, and measured brain volumes and neuropsychological performances in 13 recently abstinent young alcoholic men compared with 18 controls. No differences were found in volumetric variables between groups (intracranial volume, white matter, grey matter, anterior cingulate, insula, hippocampus, and amygdala). For the anterior cingulate, choline and creatine levels in the patient group were significantly lower than controls, and the glutamate to creatine ratio was significantly increased. These were correlated with altered short-term memory functions. Thus, neurochemical changes can occur even in the brains of young alcoholic men lacking brain atrophy.

Alteration of brain metabolites in young alcoholics without structural changes. Publishing Authors By Initials

E Lee,DP Jang,JJ Kim,SK An,S Park,IY Kim,SI Kim,KJ Yoon,K Namkoong,E Lee,DP Jang,JJ Kim,SK An,S Park,IY Kim,SI Kim,KJ Yoon,K Namkoong,

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Alteration of brain metabolites in young alcoholics without structural changes. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Neuroreport

VOLUME: 18

Page Numbers: 1511-4

Journal Abbreviation: Neuroreport

ISSN: 0959-4965

DAY: 17

MONTH: Sep

YEAR: 2007

Alteration of brain metabolites in young alcoholics without structural changes. Information

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LANGUAGE: eng

NlmUniqueID: 9100935

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Grant and Affiliation Information for Alteration of brain metabolites in young alcoholics without structural changes.

AFFILIATION: Department of Psychiatry, National Health Insurance Corporation Ilsan Hospital, Gyeonggi-do, South Korea.

Country: England

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MEDLINETA: Neuroreport

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