Alphavirus replicon particles encoding the fusion or attachment glycoproteins of respiratory syncytial virus elicit protective immune responses in BALB/c mice and functional serum antibodies in rhesus macaques.

Alphavirus replicon particles encoding the fusion or attachment glycoproteins of respiratory syncytial virus elicit protective immune responses in BALB/c mice and functional serum antibodies in rhesus macaques. Research Abstract Details 

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Alphavirus replicon particles encoding the fusion or attachment glycoproteins of respiratory syncytial virus elicit protective immune responses in BALB/c mice and functional serum antibodies in rhesus macaques. Abstract Text:

Matthew B Elliott,Tong Chen,Nicole B Terio,Siew-Yen Chong,Rashed Abdullah,Amara Luckay,Michael A Egan,Lee Anne Boutilier,Krista Melville,Robert A Lerch,Deborah Long,John H Eldridge,Christopher L Parks,Stephen A Udem,Gerald E Hancock,Matthew B Elliott,Tong Chen,Nicole B Terio,Siew-Yen Chong,Rashed Abdullah,Amara Luckay,Michael A Egan,Lee Anne Boutilier,Krista Melville,Robert A Lerch,Deborah Long,John H Eldridge,Christopher L Parks,Stephen A Udem,Gerald E Hancock,

Respiratory syncytial virus (RSV) is a major cause of acute respiratory tract disease in humans. Towards development of a prophylactic vaccine, we genetically engineered Venezuelan equine encephalitis virus (VEEV) replicons encoding the fusion (Fa) or attachment (Ga or Gb) proteins of the A or B subgroups of RSV. Intramuscular immunization with a formulation composed of equal amounts of each replicon particle (3vRSV replicon vaccine) generated serum neutralizing antibodies against A and B strains of RSV in BALB/c mice and rhesus macaques. When contrasted with purified natural protein or formalin-inactivated RSV formulated with alum, the 3vRSV replicon vaccine induced balanced Th1/Th2 T cell responses in mice. This was evident in the increased number of RSV-specific IFN-gamma(+) splenocytes following F or G peptide stimulation, diminished quantity of eosinophils and type 2 T cell cytokines in the lungs after challenge, and increased in vivo lysis of RSV peptide-loaded target cells. The immune responses in mice were also protective against intranasal challenge with RSV. Thus, the replicon-based platform represents a promising new strategy for vaccines against RSV.

Alphavirus replicon particles encoding the fusion or attachment glycoproteins of respiratory syncytial virus elicit protective immune responses in BALB/c mice and functional serum antibodies in rhesus macaques. Publishing Authors By Initials

MB Elliott,T Chen,NB Terio,SY Chong,R Abdullah,A Luckay,MA Egan,LA Boutilier,K Melville,RA Lerch,D Long,JH Eldridge,CL Parks,SA Udem,GE Hancock,MB Elliott,T Chen,NB Terio,SY Chong,R Abdullah,A Luckay,MA Egan,LA Boutilier,K Melville,RA Lerch,D Long,JH Eldridge,CL Parks,SA Udem,GE Hancock,

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Alphavirus replicon particles encoding the fusion or attachment glycoproteins of respiratory syncytial virus elicit protective immune responses in BALB/c mice and functional serum antibodies in rhesus macaques. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Vaccine

VOLUME: 25

Page Numbers: 7132-44

Journal Abbreviation: Vaccine

ISSN: 0264-410X

DAY: 21

MONTH: 08

YEAR: 2007

Alphavirus replicon particles encoding the fusion or attachment glycoproteins of respiratory syncytial virus elicit protective immune responses in BALB/c mice and functional serum antibodies in rhesus macaques. Information

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LANGUAGE: eng

NlmUniqueID: 8406899

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Grant and Affiliation Information for Alphavirus replicon particles encoding the fusion or attachment glycoproteins of respiratory syncytial virus elicit protective immune responses in BALB/c mice and functional serum antibodies in rhesus macaques.

AFFILIATION: Wyeth Research, 401 N. Middletown Road, Pearl River, NY 10965, USA. elliotm2@wyeth.com

Country: Netherlands

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MEDLINETA: Vaccine

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