alphaII-Spectrin interacts with five groups of functionally important proteins in the nucleus.

alphaII-Spectrin interacts with five groups of functionally important proteins in the nucleus. Research Abstract Details 

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alphaII-Spectrin interacts with five groups of functionally important proteins in the nucleus. Abstract Text:

Deepa M Sridharan,Laura W McMahon,Muriel W Lambert,

Nonerythroid alpha-spectrin (alphaSpIISigma( *)) is a structural protein that has been identified in the nucleus of mammalian cells and shown to be involved in DNA repair. It is also deficient in cells from the clinically diverse genetic disorder Fanconi anemia (FA). In order to get a clearer understanding of the role of alphaSpIISigma( *) in DNA repair, and whether it may have other important functions in the nucleus, studies were undertaken to identify specific alphaSpIISigma( *) protein binding partners in the nucleus. The results demonstrate that multiple proteins co-immunoprecipitate with alphaSpIISigma( *) from nuclear extracts from normal human lymphoblastoid and HeLa cells. These can be grouped into five categories: structural proteins, proteins involved in DNA repair, chromatin remodeling proteins, FA proteins, and transcription and RNA processing factors. These studies indicate that alphaSpIISigma( *) may play a role in a number of diverse and important processes in the nucleus and that a deficiency in this protein, as occurs in FA, could affect a number of critical cellular pathways.

alphaII-Spectrin interacts with five groups of functionally important proteins in the nucleus. Publishing Authors By Initials

DM Sridharan,LW McMahon,MW Lambert,

For similar genetic processes: gene expression: transcription, genetic research abstracts see: genetic processes: gene expression: transcription, genetic research

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alphaII-Spectrin interacts with five groups of functionally important proteins in the nucleus. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Cell biology international

VOLUME: 30

Page Numbers: 866-78

Journal Abbreviation: Cell Biol. Int.

ISSN: 1065-6995

DAY: 30

MONTH: 06

YEAR: 2006

alphaII-Spectrin interacts with five groups of functionally important proteins in the nucleus. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9307129

alphaII-Spectrin interacts with five groups of functionally important proteins in the nucleus. Keywords Mesh Terms:

KEYWORDS: Transcription, Genetic

MESH TERMS: metabolism

Chemical & Substance for Abstract: alphaII-Spectrin interacts with five groups of functionally important proteins in the nucleus. Information

Substance Name: Spectrin

Registry Number: 12634-43-4

Grant and Affiliation Information for alphaII-Spectrin interacts with five groups of functionally important proteins in the nucleus.

AFFILIATION: Department of Pathology and Laboratory Medicine, UMDNJ, New Jersey Medical School and the Graduate School of Biomedical Sciences, Newark, NJ 07103, USA.

Country: England

AGENCY: United States NHLBI

GRANT: R01 HL054860

ACRONYM: HL

MEDLINETA: Cell Biol Int

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