Alpha3-integrins are required for hippocampal long-term potentiation and working memory.

Alpha3-integrins are required for hippocampal long-term potentiation and working memory. Research Abstract Details 

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Alpha3-integrins are required for hippocampal long-term potentiation and working memory. Abstract Text:

Chi-Shing Chan,Jonathan M Levenson,Partha S Mukhopadhyay,Lin Zong,Allan Bradley,J David Sweatt,Ronald L Davis,

Integrins comprise a large family of heterodimeric, transmembrane cell adhesion receptors that mediate diverse neuronal functions in the developing and adult CNS. Recent pharmacological and genetic studies have suggested that beta1-integrins are critical in synaptic plasticity and memory formation. To further define the role of integrins in these processes, we generated a postnatal forebrain and excitatory neuron-specific knockout of alpha3-integrin, one of several binding partners for beta1 subunit. At hippocampal Schaffer collateral-CA1 synapses, deletion of alpha3-integrin resulted in impaired long-term potentiation (LTP). Basal synaptic transmission and paired-pulse facilitation were normal in the absence of alpha3-integrin. Behavioral studies demonstrated that the mutant mice were selectively defective in a hippocampus-dependent, nonmatch-to-place working memory task, but were normal in other hippocampus-dependent spatial tasks. The impairment in LTP and working memory is similar to that observed in beta1-integrin conditional knockout mice, suggesting that alpha3-integrin is the functional binding partner for beta1 for these processes in the forebrain.

Alpha3-integrins are required for hippocampal long-term potentiation and working memory. Publishing Authors By Initials

CS Chan,JM Levenson,PS Mukhopadhyay,L Zong,A Bradley,JD Sweatt,RL Davis,

For similar nervous system: synapses research abstracts see: nervous system: synapses research

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Alpha3-integrins are required for hippocampal long-term potentiation and working memory. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Learning & memory (Cold Spring Harbor, N.Y.)

VOLUME: 14

Page Numbers: 606-15

Journal Abbreviation: Learn. Mem.

ISSN: 1549-5485

DAY: 6

MONTH: 09

YEAR: 2007

Alpha3-integrins are required for hippocampal long-term potentiation and working memory. Information

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LANGUAGE: eng

NlmUniqueID: 9435678

Alpha3-integrins are required for hippocampal long-term potentiation and working memory. Keywords Mesh Terms:

KEYWORDS: Synapses

MESH TERMS: metabolism

Chemical & Substance for Abstract: Alpha3-integrins are required for hippocampal long-term potentiation and working memory. Information

Substance Name: Integrin alpha3

Registry Number: 0

Grant and Affiliation Information for Alpha3-integrins are required for hippocampal long-term potentiation and working memory.

AFFILIATION: Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA.

Country: United States

AGENCY: United States NIMH

GRANT: MH60420

ACRONYM: MH

MEDLINETA: Learn Mem

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