Alpha-tocopheryl succinate, the most effective form of vitamin E for adjuvant cancer treatment: a review.

Alpha-tocopheryl succinate, the most effective form of vitamin E for adjuvant cancer treatment: a review. Research Abstract Details 

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Alpha-tocopheryl succinate, the most effective form of vitamin E for adjuvant cancer treatment: a review. Abstract Text:

Kedar N Prasad,Bipin Kumar,Xiang-Dong Yan,Amy J Hanson,William C Cole,

In 1982, it was established that alpha-tocopheryl succinate (alpha-TS) was the most effective form of vitamin E in comparison to alpha-tocopherol, alpha-tocopheryl acetate and alpha-tocopheryl nicotinate in inducing differentiation, inhibition of proliferation and apoptosis in cancer cells, depending upon its concentration. During the last two decades, several studies have confirmed this observation in rodent and human cancer cells in culture and in vivo (animal model). The most exciting aspect of this alpha-TS effect is that it does not affect the proliferation of most normal cells. In spite of several studies published on the anti-cancer properties of alpha-TS, the value of this form of vitamin E has not drawn significant attention from researchers and clinicians. Therefore, a critical review on the potential role of alpha-TS in the management of cancer is needed. In addition, such a review can also provide in-depth analysis of existing literature on this subject. alpha-TS treatment causes extensive alterations in gene expression; however, only some can be attributed to differentiation, inhibition of proliferation and apoptosis. alpha-TS also enhances the growth-inhibitory effect of ionizing radiation, hyperthermia, some chemotherapeutic agents and biological response modifiers on tumor cells, while protecting normal cells against some of their adverse effects. Thus, alpha-TS alone or in combination with dietary micronutrients can be useful as an adjunct to standard cancer therapy by increasing tumor response and possibly decreasing some of the toxicities to normal cells.

Alpha-tocopheryl succinate, the most effective form of vitamin E for adjuvant cancer treatment: a review. Publishing Authors By Initials

KN Prasad,B Kumar,XD Yan,AJ Hanson,WC Cole,

For similar heterocyclic compounds: heterocyclic compounds, 2-ring: benzopyrans: vitamin e research abstracts see: heterocyclic compounds: heterocyclic compounds, 2-ring: benzopyrans: vitamin e research

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Alpha-tocopheryl succinate, the most effective form of vitamin E for adjuvant cancer treatment: a review. Journal Published:

PUBLICATION TYPE: Review

Journal: Journal of the American College of Nutrition

VOLUME: 22

Page Numbers: 108-17

Journal Abbreviation:

ISSN: 0731-5724

DAY: 19

MONTH: Apr

YEAR: 2003

Alpha-tocopheryl succinate, the most effective form of vitamin E for adjuvant cancer treatment: a review. Information

Number of References: 80

LANGUAGE: eng

NlmUniqueID: 8215879

Alpha-tocopheryl succinate, the most effective form of vitamin E for adjuvant cancer treatment: a review. Keywords Mesh Terms:

KEYWORDS: Vitamin E

MESH TERMS: therapeutic use

Chemical & Substance for Abstract: Alpha-tocopheryl succinate, the most effective form of vitamin E for adjuvant cancer treatment: a review. Information

Substance Name: tocopherol succinate

Registry Number: 17407-37-3

Grant and Affiliation Information for Alpha-tocopheryl succinate, the most effective form of vitamin E for adjuvant cancer treatment: a review.

AFFILIATION: Center for Vitamins and Cancer Research, Department of Radiology, Campus Box C-278, University of Colorado Health Sciences Center, 4200 East 9th Avenue, Denver, CO 80262, USA. kedar.prasad@UCHSC.edu

Country: United States

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MEDLINETA: J Am Coll Nutr

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