Alpha-synuclein tertiary contact dynamics.

Alpha-synuclein tertiary contact dynamics. Research Abstract Details 

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Alpha-synuclein tertiary contact dynamics. Abstract Text:

Jennifer C Lee,Bert T Lai,John J Kozak,Harry B Gray,Jay R Winkler,

Tertiary contact formation rates in alpha-synuclein, an intrinsically disordered polypeptide implicated in Parkinson's disease, have been determined from measurements of diffusion-limited electron-transfer kinetics between triplet-excited tryptophan:3-nitrotyrosine pairs separated by 10, 12, 55, and 90 residues. Calculations based on a Markovian lattice model developed to describe intrachain diffusion dynamics for a disordered polypeptide give contact quenching rates for various loop sizes ranging from 6 to 48 that are in reasonable agreement with experimentally determined values for small loops (10-20 residues). Contrary to expectations, measured contact rates in alpha-synuclein do not continue to decrease as the loop size increases (>/=35 residues), and substantial deviations from calculated rates are found for the pairs W4-Y94, Y39-W94, and W4-Y136. The contact rates for these large loops indicate much shorter average donor-acceptor separations than expected for a random polymer.

Alpha-synuclein tertiary contact dynamics. Publishing Authors By Initials

JC Lee,BT Lai,JJ Kozak,HB Gray,JR Winkler,

For similar proteins: nerve tissue proteins: synucleins: alpha-synuclein research abstracts see: proteins: nerve tissue proteins: synucleins: alpha-synuclein research

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Alpha-synuclein tertiary contact dynamics. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: The journal of physical chemistry. B

VOLUME: 111

Page Numbers: 2107-12

Journal Abbreviation:

ISSN: 1520-6106

DAY: 6

MONTH: 02

YEAR: 2007

Alpha-synuclein tertiary contact dynamics. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 101157530

Alpha-synuclein tertiary contact dynamics. Keywords Mesh Terms:

KEYWORDS: alpha-Synuclein

MESH TERMS: chemistry

Chemical & Substance for Abstract: Alpha-synuclein tertiary contact dynamics. Information

Substance Name: Tryptophan

Registry Number: 73-22-3

Grant and Affiliation Information for Alpha-synuclein tertiary contact dynamics.

AFFILIATION: Laboratory of Molecular Biophysics, National Heart, Lung, and Blood Institute, National Institutes of Health, 50 South Drive, Bethesda, Maryland 20892, USA.

Country: United States

AGENCY: United States NIGMS

GRANT: GM068461

ACRONYM: GM

MEDLINETA: J Phys Chem B

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