alpha-Chymotryptic hydrolysis of derivatives of the specific substrates with substituents in the nucleus.

alpha-Chymotryptic hydrolysis of derivatives of the specific substrates with substituents in the nucleus. Research Abstract Details 

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alpha-Chymotryptic hydrolysis of derivatives of the specific substrates with substituents in the nucleus. Abstract Text:

M Ohno,S Sato,H Mizoguchi,S Tsukamoto,

Steady state kinetic studies of alpha-chymotrypsin [EC 3.4.21.1]-catalyzed hydrolysis of nucleus-substituted derivatives of the specific substrates were made at pH 6.5 and 7.8. Ac-Trp(NCps)-OMe was hydrolyzed more readily than Ac-Trp-OMe owing to its smaller Km value. The kcat values of Ac-Trp(CHO)-OMe and Ac-Tyr(3-no2)-ome were higher than those of the corresponding unmodified substrates, suggesting that derivatives with a substituent as large as a formyl or nitro group at the epsilon-position are stereochemically favorable to the catalytic process. Derivatives of Ac-Phe-OMe with a chain of four atoms at the 3 or 4-position of the phenyl nucleus and 2,3-dihydropyrrolo[2,3-b]indoles derived from Ac-Trp-OMe were not hydrolyzed at all.

alpha-Chymotryptic hydrolysis of derivatives of the specific substrates with substituents in the nucleus. Publishing Authors By Initials

M Ohno,S Sato,H Mizoguchi,S Tsukamoto,

For similar biochemical phenomena, metabolism, and nutrition: biochemical phenomena: structure-activity relationship research abstracts see: biochemical phenomena, metabolism, and nutrition: biochemical phenomena: structure-activity relationship research

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alpha-Chymotryptic hydrolysis of derivatives of the specific substrates with substituents in the nucleus. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of biochemistry

VOLUME: 77

Page Numbers: 1341-3

Journal Abbreviation: J. Biochem.

ISSN: 0021-924X

DAY: 19

MONTH: Jun

YEAR: 1975

alpha-Chymotryptic hydrolysis of derivatives of the specific substrates with substituents in the nucleus. Information

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LANGUAGE: eng

NlmUniqueID: 376600

alpha-Chymotryptic hydrolysis of derivatives of the specific substrates with substituents in the nucleus. Keywords Mesh Terms:

KEYWORDS: Structure-Activity Relationship

MESH TERMS: metabolism

Chemical & Substance for Abstract: alpha-Chymotryptic hydrolysis of derivatives of the specific substrates with substituents in the nucleus. Information

Substance Name: Chymotrypsin

Registry Number: EC 3.4.21.1

Grant and Affiliation Information for alpha-Chymotryptic hydrolysis of derivatives of the specific substrates with substituents in the nucleus.

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Country: JAPAN

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MEDLINETA: J Biochem

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