alpha-calcium-calmodulin-dependent kinase II is associated with paired helical filaments of Alzheimer's disease.

alpha-calcium-calmodulin-dependent kinase II is associated with paired helical filaments of Alzheimer's disease. Research Abstract Details 

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alpha-calcium-calmodulin-dependent kinase II is associated with paired helical filaments of Alzheimer's disease. Abstract Text:

J Xiao,G Perry,J Troncoso,M J Monteiro,J Xiao,G Perry,J Troncoso,M J Monteiro,

Alzheimer's disease (AD) is characterized pathologically by two distinguishable deposits in the brain, namely senile plaques and neurofibrillary tangles (NFT). Senile plaques are composed of fragments of the amyloid precursor protein, whereas NFT are composed primarily of paired-helical filaments (PHF). The latter are in turn composed principally of the microtubule-associated protein, tau. Tau in PHF is highly and unusually phosphorylated but the mechanisms leading to this unusual phosphorylation are not known. Using a combination of immunoblotting and kinase assays, we demonstrate that a discreet set of kinases copurify with PHF. One of these kinases was found by immunoblotting to be alpha-calcium-calmodulin-dependent kinase II (alpha-CaM kinase). Immunogold labeling revealed that alpha-CaM kinase was localized to a novel globular membranelike structure found at the ends of PHF. Since previous studies have shown alpha-CaM kinase to be involved in memory, its association with PHF may have important implications in understanding memory loss in AD. We also discuss the possibility that the association of alpha-CaM kinase with PHF may indicate sites where tau protein is converted into PHF.

alpha-calcium-calmodulin-dependent kinase II is associated with paired helical filaments of Alzheimer's disease. Publishing Authors By Initials

J Xiao,G Perry,J Troncoso,MJ Monteiro,J Xiao,G Perry,J Troncoso,MJ Monteiro,

For similar biochemical phenomena, metabolism, and nutrition: biochemical phenomena: protein binding research abstracts see: biochemical phenomena, metabolism, and nutrition: biochemical phenomena: protein binding research

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alpha-calcium-calmodulin-dependent kinase II is associated with paired helical filaments of Alzheimer's disease. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Journal of neuropathology and experimental neurolo

VOLUME: 55

Page Numbers: 954-63

Journal Abbreviation: J. Neuropathol. Exp. Neurol.

ISSN: 0022-3069

DAY: 16

MONTH: Sep

YEAR: 1996

alpha-calcium-calmodulin-dependent kinase II is associated with paired helical filaments of Alzheimer's disease. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 2985192

alpha-calcium-calmodulin-dependent kinase II is associated with paired helical filaments of Alzheimer's disease. Keywords Mesh Terms:

KEYWORDS: Protein Binding

MESH TERMS: physiology

Chemical & Substance for Abstract: alpha-calcium-calmodulin-dependent kinase II is associated with paired helical filaments of Alzheimer's disease. Information

Substance Name: Calcium-Calmodulin-Dependent Protein Kin

Registry Number: EC 2.7.11.17

Grant and Affiliation Information for alpha-calcium-calmodulin-dependent kinase II is associated with paired helical filaments of Alzheimer's disease.

AFFILIATION: Medical Biotechnology Center of the University of Maryland Biotechnology Institute, University of Maryland School of Medicine, Baltimore 21205, USA.

Country: UNITED STATES

AGENCY: United States NIA

GRANT: AG11386

ACRONYM: AG

MEDLINETA: J Neuropathol Exp Neurol

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