Alpha C protein-specific immunity in humans with group B streptococcal colonization and invasive disease.

Alpha C protein-specific immunity in humans with group B streptococcal colonization and invasive disease. Research Abstract Details 

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Alpha C protein-specific immunity in humans with group B streptococcal colonization and invasive disease. Abstract Text:

Pia S Pannaraj,Joanna K Kelly,Marcia A Rench,Lawrence C Madoff,Morven S Edwards,Carol J Baker,

Alpha C protein, found in 76% of non-type III strains of group B Streptococcus (GBS), elicits antibodies protective against alpha C-expressing strains in experimental animals, making it an appealing carrier for a GBS conjugate vaccine. We determined whether natural exposure to alpha C elicits antibodies in women. Geometric mean concentrations of alpha C-specific IgM and IgG were similar by ELISA in sera from 58 alpha C GBS strain colonized and 174 age-matched non-colonized women (IgG 245 and 313ng/ml; IgM 257 and 229ng/ml, respectively), but acute sera from 13 women with invasive alpha C-expressing GBS infection had significantly higher concentrations (IgM 383 and IgG 476ng/ml [p=0.036 and 0.038, respectively]). Convalescent sera from 5 of these women 16-49 days later had high alpha C-specific IgM and IgG concentrations (1355 and 4173ng/ml, respectively). In vitro killing of alpha C-expressing GBS correlated with total alpha C-specific antibody concentration. Invasive disease but not colonization elicits alpha C-specific IgM and IgG in adults.

Alpha C protein-specific immunity in humans with group B streptococcal colonization and invasive disease. Publishing Authors By Initials

PS Pannaraj,JK Kelly,MA Rench,LC Madoff,MS Edwards,CJ Baker,

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Alpha C protein-specific immunity in humans with group B streptococcal colonization and invasive disease. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Vaccine

VOLUME: 26

Page Numbers: 502-8

Journal Abbreviation: Vaccine

ISSN: 0264-410X

DAY: 3

MONTH: 12

YEAR: 2007

Alpha C protein-specific immunity in humans with group B streptococcal colonization and invasive disease. Information

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LANGUAGE: eng

NlmUniqueID: 8406899

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Grant and Affiliation Information for Alpha C protein-specific immunity in humans with group B streptococcal colonization and invasive disease.

AFFILIATION: Section of Infectious Diseases, Department of Pediatrics, Baylor College of Medicine and Texas Children's Hospital, Houston, TX, United States.

Country: Netherlands

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MEDLINETA: Vaccine

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