Allopeptide-specific CD4(+) T cells facilitate the differentiation of directly alloreactive graft-infiltrating CD8(+) T Cells.

Allopeptide-specific CD4(+) T cells facilitate the differentiation of directly alloreactive graft-infiltrating CD8(+) T Cells. Research Abstract Details 

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Allopeptide-specific CD4(+) T cells facilitate the differentiation of directly alloreactive graft-infiltrating CD8(+) T Cells. Abstract Text:

D M Richards,N Zhang,S L Dalheimer,D L Mueller,

To investigate the mechanism of CD4(+) T-cell help during the activation and differentiation of directly alloreactive CD8(+) T cells, we examined the development of obliterative airways disease (OAD) following transplantation of airways into fully mismatched recipient mice deficient in CD4(+) T cells. BALB/c trachea allografts became fibrosed significantly less frequently in B6 CD4(-/-) recipients as compared to wildtype controls. Furthermore, class I-directed cytotoxicity failed to develop in the absence of CD4(+) T cells. The infiltration of graft tissue by primed L(d)-specific directly alloreactive 2C CD8(+) T cells was not found to depend on the presence of CD4(+) T cells. Nevertheless, graft-infiltrating 2C CD8(+) T cells failed to express CD69 and granzyme B when CD4(+) T-cell help was unavailable. Importantly, reconstitution of B6 CD4(-/-) recipient mice with graft peptide-specific TCR-Tg CD4(+) T cells (OT-II or TEa) capable of recognizing antigen only on recipient APC allowed for full expression of CD69 and granzyme B by the directly alloreactive CD8(+) T cells and restored the capacity of recipients to reject their allografts. These results demonstrate that indirectly alloreactive CD4(+) T cells ensure the optimal activation and differentiation of graft-infiltrating directly alloreactive CD8(+) T cells independent of donor APC recognition.

Allopeptide-specific CD4(+) T cells facilitate the differentiation of directly alloreactive graft-infiltrating CD8(+) T Cells. Publishing Authors By Initials

DM Richards,N Zhang,SL Dalheimer,DL Mueller,

For similar surgical procedures, operative: transplantation: transplantation, homologous research abstracts see: surgical procedures, operative: transplantation: transplantation, homologous research

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Allopeptide-specific CD4(+) T cells facilitate the differentiation of directly alloreactive graft-infiltrating CD8(+) T Cells. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: American journal of transplantation : official jou

VOLUME: 7

Page Numbers: 2269-78

Journal Abbreviation: Am. J. Transplant.

ISSN: 1600-6135

DAY: 3

MONTH: Oct

YEAR: 2007

Allopeptide-specific CD4(+) T cells facilitate the differentiation of directly alloreactive graft-infiltrating CD8(+) T Cells. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 100968638

Allopeptide-specific CD4(+) T cells facilitate the differentiation of directly alloreactive graft-infiltrating CD8(+) T Cells. Keywords Mesh Terms:

KEYWORDS: Transplantation, Homologous

MESH TERMS: pathology

Chemical & Substance for Abstract: Allopeptide-specific CD4(+) T cells facilitate the differentiation of directly alloreactive graft-infiltrating CD8(+) T Cells. Information

Substance Name: CD69 antigen

Registry Number: 0

Grant and Affiliation Information for Allopeptide-specific CD4(+) T cells facilitate the differentiation of directly alloreactive graft-infiltrating CD8(+) T Cells.

AFFILIATION: Department of Medicine, and Center for Immunology, University of Minnesota Medical School, Minneapolis, MN, USA.

Country: Denmark

AGENCY: United States NHLBI

GRANT: T32 HL07741

ACRONYM: HL

MEDLINETA: Am J Transplant

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