Allo-limbal transplantation in patients with limbal stem cell deficiency.

Allo-limbal transplantation in patients with limbal stem cell deficiency. Research Abstract Details 

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Allo-limbal transplantation in patients with limbal stem cell deficiency. Abstract Text:

AIM: To report the outcome of a series of patients with stem cell deficiency who underwent allo-limbal transplantation and to describe a technique for this procedure. METHODS: Six consecutive patients underwent allo-limbal stem cell transplantation. The primary diagnosis included alkali burn (n = 2), trachoma (n = 1), chronic rosacea blepharitis and kerato-conjunctivitis (n = 1), aniridia (n = 1), and Stevens-Johnson syndrome (n = 1). The limbal rim consisted of peripheral cornea and perilimbal sclera. FK-506 was used postoperatively for immunosuppression. RESULTS: The length of follow up ranged from 3 to 24 months (mean follow up 11.8 (SD 9.3) months). The outcome was considered satisfactory in five of six cases. The corneal surface was completely epithelialised within 2 weeks, and there was a substantial improvement in vision and symptoms. One patient had recurrent epithelial defects related to eyelid abnormalities. No side effects associated with systemic immunosuppression were noted. CONCLUSION: Allo-limbal transplantation, with systemic immunosuppression with FK-506 is useful in reconstruction of the ocular surface with improvement in vision in patients with severe stem cell deficiency.

Allo-limbal transplantation in patients with limbal stem cell deficiency. Publishing Authors By Initials

For similar surgical procedures, operative: transplantation: cell transplantation: stem cell transplantation research abstracts see: surgical procedures, operative: transplantation: cell transplantation: stem cell transplantation research

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Allo-limbal transplantation in patients with limbal stem cell deficiency. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: The British journal of ophthalmology

VOLUME: 83

Page Numbers: 414-9

Journal Abbreviation: Br J Ophthalmol

ISSN: 0007-1161

DAY: 28

MONTH: Apr

YEAR: 1999

Allo-limbal transplantation in patients with limbal stem cell deficiency. Information

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LANGUAGE: eng

NlmUniqueID: 421041

Allo-limbal transplantation in patients with limbal stem cell deficiency. Keywords Mesh Terms:

KEYWORDS: Stem Cell Transplantation

MESH TERMS: surgery

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Grant and Affiliation Information for Allo-limbal transplantation in patients with limbal stem cell deficiency.

AFFILIATION: Department of Ophthalmology, Queen's Medical Centre, University Hospital, Nottingham.

Country: ENGLAND

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MEDLINETA: Br J Ophthalmol

REFSOURCE: Br J Ophthalmol. 1999 Dec;83(12):1409-10

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