Allergy-related polymorphisms influence glioma status and serum IgE levels.

Allergy-related polymorphisms influence glioma status and serum IgE levels. Research Abstract Details 

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Allergy-related polymorphisms influence glioma status and serum IgE levels. Abstract Text:

Joseph L Wiemels,John K Wiencke,Karl T Kelsey,Michelle Moghadassi,Terri Rice,Kevin Y Urayama,Rei Miike,Margaret Wrensch,

Previous studies have shown that glioma patients report allergies less frequently than controls, harbor lower atopy-associated IgE levels, and harbor different frequencies of polymorphisms in the IL13 and IL4 pathways than controls. We sought to confirm this latter result and extend the analysis to IgE levels. Glioma patients (n = 456) and controls (n = 541) were genotyped for genetic variants in IL4, IL4R, and IL13 and tested for total IgE levels (n = 248 controls and 289 cases). Among Whites, IL4 and IL4R polymorphisms and haplotypes were neither significantly associated with IgE levels in controls nor associated with glioma status. IL13 R110G and C-1112T were associated with increased IgE levels in controls (P < 0.001 and P = 0.04, respectively), and IL13 C-1112T was inversely associated with case-control status (P = 0.05, test for trend in dose model). An IL4R haplotype was borderline associated with increased risk in case-control analysis [odds ratio (OR), 1.5; 95% confidence interval (95% CI), 1.0-2.3]. In addition, a rare haplotype for IL4 was associated with decreased risk (OR, 0.23; 95% CI, 0.07-0.83), and a common haplotype in IL13 was associated with decreased risk (OR, 0.73; 95% CI, 0.53-1.00). Our data provide evidence for a role of IL13 polymorphisms on IgE levels and a role for IL4, IL4R, and IL13 haplotypes on case-control status. We did not find any evidence that the interleukin (IL) polymorphisms exerted their effect on glioma risk via their effects on IgE levels. Further exploration of immune susceptibility factors, including genetics, in glioma etiology is advisable.

Allergy-related polymorphisms influence glioma status and serum IgE levels. Publishing Authors By Initials

JL Wiemels,JK Wiencke,KT Kelsey,M Moghadassi,T Rice,KY Urayama,R Miike,M Wrensch,

For similar proteins: membrane proteins: receptors, cell surface: receptors, immunologic: receptors, cytokine: receptors, interleukin: receptors, interleukin-4 research abstracts see: proteins: membrane proteins: receptors, cell surface: receptors, immunologic: receptors, cytokine: receptors, interleukin: receptors, interleukin-4 research

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MEDLINE DATE:

Allergy-related polymorphisms influence glioma status and serum IgE levels. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Cancer epidemiology, biomarkers & prevention : a p

VOLUME: 16

Page Numbers: 1229-35

Journal Abbreviation: Cancer Epidemiol. Biomarkers P

ISSN: 1055-9965

DAY: 3

MONTH: Jun

YEAR: 2007

Allergy-related polymorphisms influence glioma status and serum IgE levels. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9200608

Allergy-related polymorphisms influence glioma status and serum IgE levels. Keywords Mesh Terms:

KEYWORDS: Receptors, Interleukin-4

MESH TERMS: genetics

Chemical & Substance for Abstract: Allergy-related polymorphisms influence glioma status and serum IgE levels. Information

Substance Name: Immunoglobulin E

Registry Number: 37341-29-0

Grant and Affiliation Information for Allergy-related polymorphisms influence glioma status and serum IgE levels.

AFFILIATION: Department of Epidemiology and Biostatistics, University of California at San Francisco, San Francisco, CA 94143-0441, USA. joe.wiemels@ucsf.edu

Country: United States

AGENCY: United States NCI

GRANT: CA89032

ACRONYM: CA

MEDLINETA: Cancer Epidemiol Biomarkers Pr

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