Allergens induce enhanced bronchoconstriction and leukotriene production in C5 deficient mice.

Allergens induce enhanced bronchoconstriction and leukotriene production in C5 deficient mice. Research Abstract Details 

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Allergens induce enhanced bronchoconstriction and leukotriene production in C5 deficient mice. Abstract Text:

Laura McKinley,Jiyoun Kim,Gerald L Bolgos,Javed Siddiqui,Daniel G Remick,

BACKGROUND: Previous genetic analysis has shown that a deletion in the complement component 5 gene-coding region renders mice more susceptible to allergen-induced airway hyperresponsiveness (AHR) due to reduced IL-12 production. We investigated the role of complement in a murine model of asthma-like pulmonary inflammation. METHODS: In order to evaluate the role of complement B10 mice either sufficient or deficient in C5 were studied. Both groups of mice immunized and challenged with a house dust extract (HDE) containing high levels of cockroach allergens. Airways hyper-reactivity was determined with whole-body plesthysmography. Bronchoalveolar lavage (BAL) was performed to determine pulmonary cellular recruitment and measure inflammatory mediators. Lung homogenates were assayed for mediators and plasma levels of IgE determined. Pulmonary histology was also evaluated. RESULTS: C5-deficient mice showed enhanced AHR to methylcholine challenge, 474% and 91% increase above baseline Penh in C5-deficient and C5-sufficient mice respectively, p < 0.001. IL-12 levels in the lung homogenate (LH) were only slightly reduced and BAL IL-12 was comparable in C5-sufficient and C5-deficient mice. However, C5-deficient mice had significantly higher cysteinyl-leukotriene levels in the BAL fluid, 1913 +/- 246 pg/ml in C5d and 756 +/- 232 pg/ml in C5-sufficient, p = 0.003. CONCLUSION: These data demonstrate that C5-deficient mice show enhanced AHR due to increased production of cysteinyl-leukotrienes.

Allergens induce enhanced bronchoconstriction and leukotriene production in C5 deficient mice. Publishing Authors By Initials

L McKinley,J Kim,GL Bolgos,J Siddiqui,DG Remick,

For similar respiratory tract diseases: respiratory hypersensitivity research abstracts see: respiratory tract diseases: respiratory hypersensitivity research

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Allergens induce enhanced bronchoconstriction and leukotriene production in C5 deficient mice. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Respiratory research

VOLUME: 7

Page Numbers: 129

Journal Abbreviation: Respir. Res.

ISSN: 1465-993X

DAY: 17

MONTH: 10

YEAR: 2006

Allergens induce enhanced bronchoconstriction and leukotriene production in C5 deficient mice. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 101090633

Allergens induce enhanced bronchoconstriction and leukotriene production in C5 deficient mice. Keywords Mesh Terms:

KEYWORDS: Respiratory Hypersensitivity

MESH TERMS: prevention & control

Chemical & Substance for Abstract: Allergens induce enhanced bronchoconstriction and leukotriene production in C5 deficient mice. Information

Substance Name: Choline

Registry Number: 62-49-7

Grant and Affiliation Information for Allergens induce enhanced bronchoconstriction and leukotriene production in C5 deficient mice.

AFFILIATION: Department of Pathology, University of Michigan, Ann Arbor, MI, USA. Laura.McKinley@chp.edu

Country: England

AGENCY: United States NIEHS

GRANT: ES 09589

ACRONYM: ES

MEDLINETA: Respir Res

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