Allele-specific histone modifications regulate expression of the Dlk1-Gtl2 imprinted domain.

Allele-specific histone modifications regulate expression of the Dlk1-Gtl2 imprinted domain. Research Abstract Details 

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Allele-specific histone modifications regulate expression of the Dlk1-Gtl2 imprinted domain. Abstract Text:

Michael S Carr,Aleksey Yevtodiyenko,Claudia L Schmidt,Jennifer V Schmidt,

Dlk1 and Gtl2 are reciprocally expressed imprinted genes located on mouse chromosome 12. The Dlk1-Gtl2 locus carries three differentially methylated regions (DMRs), which are methylated only on the paternal allele. Of these, the intergenic (IG) DMR, located 12 kb upstream of Gtl2, is required for proper imprinting of linked genes on the maternal chromosome, while the Gtl2 DMR, located across the promoter of the Gtl2 gene, is implicated in imprinting on both parental chromosomes. In addition to DNA methylation, modification of histone proteins is also an important regulator of imprinted gene expression. Chromatin immunoprecipitation was therefore used to examine the pattern of histone modifications across the IG and Gtl2 DMRs. The data show maternal-specific histone acetylation at the Gtl2 DMR, but not at the IG DMR. In contrast, only low levels of histone methylation were observed throughout the region, and there was no difference between the two parental alleles. An existing mouse line carrying a deletion/insertion upstream of Gtl2 is unable to imprint the Dlk1-Gtl2 locus properly and demonstrates loss of allele-specific methylation at the Gtl2 DMR. Further analysis of these animals now shows that the loss of allele-specific methylation is accompanied by increased paternal histone acetylation at the Gtl2 DMR, with the activated paternal allele adopting a maternal acetylation pattern. These data indicate that interactions between DNA methylation and histone acetylation are involved in regulating the imprinting of the Dlk1-Gtl2 locus.

Allele-specific histone modifications regulate expression of the Dlk1-Gtl2 imprinted domain. Publishing Authors By Initials

MS Carr,A Yevtodiyenko,CL Schmidt,JV Schmidt,

For similar proteins: dna-binding proteins: erythroid-specific dna-binding factors: yy1 transcription factor research abstracts see: proteins: dna-binding proteins: erythroid-specific dna-binding factors: yy1 transcription factor research

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MEDLINE DATE:

Allele-specific histone modifications regulate expression of the Dlk1-Gtl2 imprinted domain. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Genomics

VOLUME: 89

Page Numbers: 280-90

Journal Abbreviation: Genomics

ISSN: 0888-7543

DAY: 27

MONTH: 11

YEAR: 2006

Allele-specific histone modifications regulate expression of the Dlk1-Gtl2 imprinted domain. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8800135

Allele-specific histone modifications regulate expression of the Dlk1-Gtl2 imprinted domain. Keywords Mesh Terms:

KEYWORDS: YY1 Transcription Factor

MESH TERMS: metabolism

Chemical & Substance for Abstract: Allele-specific histone modifications regulate expression of the Dlk1-Gtl2 imprinted domain. Information

Substance Name: DNA

Registry Number: 9007-49-2

Grant and Affiliation Information for Allele-specific histone modifications regulate expression of the Dlk1-Gtl2 imprinted domain.

AFFILIATION: Department of Biological Sciences, The University of Illinois at Chicago, 900 S. Ashland Avenue, MC 567, Chicago, IL 60607, USA.

Country: United States

AGENCY: United States NICHD

GRANT: R01 HD042013-01A2

ACRONYM: HD

MEDLINETA: Genomics

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