Aligning families of two-dimensional gels by a combined multiresolution forward-inverse transformation approach.

Aligning families of two-dimensional gels by a combined multiresolution forward-inverse transformation approach. Research Abstract Details 

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Aligning families of two-dimensional gels by a combined multiresolution forward-inverse transformation approach. Abstract Text:

Florian A Potra,Xing Liu,

A new method for aligning families of two-dimensional polyacrylamide gel electrophoresis (2D-PAGE) images arising in proteomics studies is presented. Forward piecewise bilinear transformations are used to determine an ideal gel and to obtain an initial alignment of the family of gels to this ideal gel. Both the ideal landmarks and the coefficients defining the transformations are obtained by solving a quadratic programming problem. The alignment is then improved by using inverse transformations on finer grids. Numerical results for a family of 123 gels are reported.

Aligning families of two-dimensional gels by a combined multiresolution forward-inverse transformation approach. Publishing Authors By Initials

FA Potra,X Liu,

For similar biological sciences: biochemistry: proteomics research abstracts see: biological sciences: biochemistry: proteomics research

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Aligning families of two-dimensional gels by a combined multiresolution forward-inverse transformation approach. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Journal of computational biology : a journal of co

VOLUME: 13

Page Numbers: 1384-95

Journal Abbreviation: J. Comput. Biol.

ISSN: 1066-5277

DAY: 3

MONTH: Sep

YEAR: 2006

Aligning families of two-dimensional gels by a combined multiresolution forward-inverse transformation approach. Information

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LANGUAGE: eng

NlmUniqueID: 9433358

Aligning families of two-dimensional gels by a combined multiresolution forward-inverse transformation approach. Keywords Mesh Terms:

KEYWORDS: Proteomics

MESH TERMS: methods

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Grant and Affiliation Information for Aligning families of two-dimensional gels by a combined multiresolution forward-inverse transformation approach.

AFFILIATION: Department of Mathematics and Statistics, UMBC, 1000 Hilltop Circle, Baltimore, Maryland 21250, USA. potra@math.umbc.edu

Country: United States

AGENCY: United States NIGMS

GRANT: 1R01GM075298-01

ACRONYM: GM

MEDLINETA: J Comput Biol

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