Aldosterone impairs baroreflex sensitivity in healthy adults.

Aldosterone impairs baroreflex sensitivity in healthy adults. Research Abstract Details 

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Aldosterone impairs baroreflex sensitivity in healthy adults. Abstract Text:

Kevin D Monahan,Urs A Leuenberger,Chester A Ray,

Animal studies suggest that acute and chronic aldosterone administration impairs baroreceptor/baroreflex responses. We tested the hypothesis that aldosterone impairs baroreflex control of cardiac period [cardiovagal baroreflex sensitivity (BRS)] and muscle sympathetic nerve activity (MSNA, sympathetic BRS) in humans. Twenty-six young (25 +/- 1 yr old, mean +/- SE) adults were examined in this study. BRS was determined by using the modified Oxford technique (bolus infusion of nitroprusside, followed 60 s later by bolus infusion of phenylephrine) in triplicate before (Pre) and 30-min after (Post) beginning aldosterone (experimental, 12 pmol.kg(-1).min(-1); n = 10 subjects) or saline infusion (control; n = 10). BRS was quantified from the R-R interval-systolic blood pressure (BP) (cardiovagal BRS) and MSNA-diastolic BP (sympathetic BRS) relations. Aldosterone infusion increased serum aldosterone levels approximately fourfold (P < 0.05) and decreased (P < 0.05) cardiovagal (19.0 +/- 2.3 vs. 15.6 +/- 1.7 ms/mmHg Pre and Post, respectively) and sympathetic BRS [-4.4 +/- 0.4 vs. -3.0 +/- 0.4 arbitrary units (AU).beat(-1).mmHg(-1)]. In contrast, neither cardiovagal (19.3 +/- 3.3 vs. 20.2 +/- 3.3 ms/mmHg) nor sympathetic BRS (-3.8 +/- 0.5 vs. -3.6 +/- 0.5 AU.beat(-1).mmHg(-1)) were altered (Pre vs. Post) in the control group. BP, heart rate, and MSNA at rest were similar in experimental and control subjects before and after the intervention. Additionally, neural and cardiovascular responses to a cold pressor test and isometric handgrip to fatigue were unaffected by aldosterone infusion (n = 6 subjects). These data provide direct experimental support for the concept that aldosterone impairs baroreflex function (cardiovagal and sympathetic BRS) in humans. Therefore, aldosterone may be an important determinant/modulator of baroreflex function in humans.

Aldosterone impairs baroreflex sensitivity in healthy adults. Publishing Authors By Initials

KD Monahan,UA Leuenberger,CA Ray,

For similar nervous system: peripheral nervous system: autonomic nervous system: autonomic pathways: vagus nerve research abstracts see: nervous system: peripheral nervous system: autonomic nervous system: autonomic pathways: vagus nerve research

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Aldosterone impairs baroreflex sensitivity in healthy adults. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: American journal of physiology. Heart and circulat

VOLUME: 292

Page Numbers: H190-7

Journal Abbreviation: Am. J. Physiol. Heart Circ. Ph

ISSN: 0363-6135

DAY: 18

MONTH: 08

YEAR: 2006

Aldosterone impairs baroreflex sensitivity in healthy adults. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 100901228

Aldosterone impairs baroreflex sensitivity in healthy adults. Keywords Mesh Terms:

KEYWORDS: Vagus Nerve

MESH TERMS: physiology

Chemical & Substance for Abstract: Aldosterone impairs baroreflex sensitivity in healthy adults. Information

Substance Name: Aldosterone

Registry Number: 52-39-1

Grant and Affiliation Information for Aldosterone impairs baroreflex sensitivity in healthy adults.

AFFILIATION: Penn State Heart and Vascular Institute, The Milton S. Hershey Medical Center, Campus Box H047, 500 University Dr., Hershey, PA 17033-2390, USA. kmonahan@psu.edu

Country: United States

AGENCY: United States NCRR

GRANT: M01-RR-10732

ACRONYM: RR

MEDLINETA: Am J Physiol Heart Circ Physio

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