Aldosterone and end-organ damage.

Aldosterone and end-organ damage. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Aldosterone and end-organ damage. Abstract Text:

Annis M Marney,Nancy J Brown,

Aldosterone concentrations are inappropriately high in many patients with hypertension, as well as in an increasing number of individuals with metabolic syndrome and sleep apnoea. A growing body of evidence suggests that aldosterone and/or activation of the MR (mineralocorticoid receptor) contributes to cardiovascular remodelling and renal injury in these conditions. In addition to causing sodium retention and increased blood pressure, MR activation induces oxidative stress, endothelial dysfunction, inflammation and subsequent fibrosis. The MR may be activated by aldosterone and cortisol or via transactivation by the AT(1) (angiotenin II type 1) receptor through a mechanism involving the EGFR (epidermal growth factor receptor) and MAPK (mitogen-activated protein kinase) pathway. In addition, aldosterone can generate rapid non-genomic effects in the heart and vasculature. MR antagonism reduces mortality in patients with CHF (congestive heart failure) and following myocardial infarction. MR antagonism improves endothelial function in patients with CHF, reduces circulating biomarkers of cardiac fibrosis in CHF or following myocardial infarction, reduces blood pressure in resistant hypertension and decreases albuminuria in hypertensive and diabetic patients. In contrast, whereas adrenalectomy improves glucose homoeostasis in hyperaldosteronism, MR antagonism may worsen glucose homoeostasis and impairs endothelial function in diabetes, suggesting a possible detrimental effect of aldosterone via non-genomic pathways.

Aldosterone and end-organ damage. Publishing Authors By Initials

AM Marney,NJ Brown,

For similar biochemical phenomena, metabolism, and nutrition: metabolism: renin-angiotensin system research abstracts see: biochemical phenomena, metabolism, and nutrition: metabolism: renin-angiotensin system research

PUBMED ID PMID:

MEDLINE DATE:

Aldosterone and end-organ damage. Journal Published:

PUBLICATION TYPE: Review

Journal: Clinical science (London, England : 1979)

VOLUME: 113

Page Numbers: 267-78

Journal Abbreviation: Clin. Sci.

ISSN: 1470-8736

DAY: 3

MONTH: Sep

YEAR: 2007

Aldosterone and end-organ damage. Information

Number of References: 130

LANGUAGE: eng

NlmUniqueID: 7905731

Aldosterone and end-organ damage. Keywords Mesh Terms:

KEYWORDS: Renin-Angiotensin System

MESH TERMS: physiology

Chemical & Substance for Abstract: Aldosterone and end-organ damage. Information

Substance Name: Aldosterone

Registry Number: 52-39-1

Grant and Affiliation Information for Aldosterone and end-organ damage.

AFFILIATION: Division of Clinical Pharmacology, Departments of Medicine and Pharmacology, Vanderbilt University Medical Center, Nashville, TN 37232-6602, USA.

Country: England

AGENCY: United States NHLBI

GRANT: HL067308

ACRONYM: HL

MEDLINETA: Clin Sci (Lond)

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Aldosterone and end-organ damage Related Publications

• A radioimmunoassay method for the determination of nedocromil sodium in plasma and urine.
• ABCB1 2677G>T/A genotype and paclitaxel pharmacogenetics in ovarian cancer.
• Age-related macular degeneration: self-management and reduction of depressive symptoms in a randomized, controlled study.
• Application of item response theory to quantify substance use disorder severity.
• Cell structure and mobilization of lipids and proteins from cotyledon under microgravity influence.
• Chemokine receptors : therapeutic potential in asthma.
• Circadian rhythms. Chronobiology--reducing time.
• Comparative gene expression by WC1+ gammadelta and CD4+ alphabeta T lymphocytes, which respond to Anaplasma marginale, demonstrates higher expression of chemokines and other myeloid cell-associated genes by WC1+ gammadelta T cells.
• Effect of gonadotrophin releasing hormone on conception rate in repeat-breeder dairy cows.
• Engineered iron oxide-adhesion mutants of the Escherichia coli phage lambda receptor.
• Epigenetic silencing of the tumor suppressor cystatin M occurs during breast cancer progression.
• From tip-of-the-tongue (TOT) data to theoretical implications in two steps: when more TOTs means better retrieval.
• Gravisensing: ionic responses, cytoskeleton and amyloplast behavior.
• Identifying housing that poisons: a critical step in eliminating childhood lead poisoning.
• Impaired trace and contextual fear conditioning in aged rats.
• In vivo metabolism of alpha-tocopherol in lipoproteins and liver: studies on rabbits in response to acute cholesterol loading.
• LIPID arrays: new tools in the understanding of membrane dynamics and lipid signaling.
• Loading and boundary condition influences in a poroelastic finite element model of cartilage stresses in a triaxial compression bioreactor.
• Meta-analysis of the effect of exercise interventions on fitness outcomes among adults with type 1 and type 2 diabetes.
• Prenatal diagnostic testing for infantile and late-infantile neuronal ceroid lipofusinoses (NCL) using allele specific primer extension (ASPE).
• Quantitative analysis reveals differential expression of mucin (MUC2) and intestinal trefoil factor mRNAs along the longitudinal axis of rat intestine.
• RHO SIGNALING in vascular diseases.
• Regio- and stereoselective glycosylation: synthesis of 5-haloimidazole alpha-ribonucleosides.
• Solid-state 2H NMR structure of retinal in metarhodopsin I.
• Spermagglutinins in serum and seminal fluid of bulls and their relationship to fertility classification.
• Stimulatory effect of genistein and apigenin on the growth of breast cancer cells correlates with their ability to activate ER alpha.
• Taste receptors in the gastrointestinal tract. II. L-amino acid sensing by calcium-sensing receptors: implications for GI physiology.
• Transforming growth factor beta receptor family ligands inhibit hepatocyte growth factor synthesis and secretion from astrocytoma cells.
• Treatment of the severe refractory irritable bowel patient.
• Working with a Head Start population with asthma: lessons learned.