Alcohol and lipid metabolism.

Alcohol and lipid metabolism. Research Abstract Details 

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Alcohol and lipid metabolism. Abstract Text:

Many new mechanisms for alcoholic steatosis have been suggested by work reported in the last five years. These include alterations of transcriptional controls of lipid metabolism, better understanding of the effects of abnormal methionine metabolism on the endoplasmic reticulum stress response, unraveling of the basis for sensitization of the Kupffer cell to lipopolysaccharide, a better understanding of the role of cytokines and adipokines in alcoholic liver disease, and implication of the innate immune and complement systems in responses to alcohol. Much of this work has been facilitated by work with knockout mice. Undoubtedly, there are interrelationships among these various pathogenic mechanisms that ultimately will provide a more cohesive picture of how heavy alcohol use deranges hepatic lipid metabolism.

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PUBLICATION TYPE: Journal Article

Journal: American journal of physiology. Endocrinology and

VOLUME: 295

Page Numbers: E10-6

Journal Abbreviation: Am. J. Physiol. Endocrinol. Me

ISSN: 0193-1849

DAY: 18

MONTH: 03

YEAR: 2008

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LANGUAGE: eng

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Grant and Affiliation Information for Alcohol and lipid metabolism.

AFFILIATION: Indiana Univ. School of Medicine, 545 Barnhill Dr., Indianapolis, IN 46202. dcrabb@iupui.edu).

Country: United States

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MEDLINETA: Am J Physiol Endocrinol Metab

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