Alcohol and fibrogenesis.

Alcohol and fibrogenesis. Research Abstract Details 

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Alcohol and fibrogenesis. Abstract Text:

In addition to fibrosis in response to necrosis and inflammation, alcohol may promote fibrogenesis directly, resulting in pericellular, perisinusoidal and perivenular fibrosis, in association with increased collagen mRNA. Acetaldehyde (produced in increased amounts because of the selective induction of cytochrome P450IIE1) stimulates collagen formation from either myofibroblasts, Ito cells or fibroblasts. One postulated mechanism is adduct formation of acetaldehyde with intracellular proteins, possibly stabilized by the NADH generated upon ethanol oxidation. The latter also increases lactate which might inhibit proline oxidase activity and increase available proline. During the initial stage of alcohol consumption, collagenase activity is increased, in keeping with enhanced collagen production. In later stages, however, there is a secondary decrease of collagenase activity; its deficiency relative to synthesis may also promote collagen deposition. In the early stage of alcohol induced fibrosis, collagens type I and type III accumulate, whereas later, type I predominates. Both can be formed in vitro by Ito cells, but cultured hepatocytes produce mainly type III. Immunohistochemical techniques revealed the deposition of type III procollagen in the extrahepatic collagen fibrils. Its degradation, as well as its enhanced synthesis, contribute to the appearance of procollagen III peptides in the blood. Their measurement by Fab fragments of the antibody is useful to assess the degree of fibrosis and to detect perivenular fibrosis, a precirrhotic lesion. In the baboon model, polyunsaturated lecithin was found to be effective in opposing alcohol-induced fibrosis.

Alcohol and fibrogenesis. Publishing Authors By Initials

For similar digestive system diseases: liver diseases: liver cirrhosis: liver cirrhosis, alcoholic research abstracts see: digestive system diseases: liver diseases: liver cirrhosis: liver cirrhosis, alcoholic research

PUBMED ID PMID:

MEDLINE DATE:

Alcohol and fibrogenesis. Journal Published:

PUBLICATION TYPE: Review

Journal: Alcohol and alcoholism (Oxford, Oxfordshire). Supp

VOLUME: 1

Page Numbers: 339-44

Journal Abbreviation:

ISSN: 1358-6173

DAY: 26

MONTH: 02

YEAR: 1991

Alcohol and fibrogenesis. Information

Number of References: 49

LANGUAGE: eng

NlmUniqueID: 8804836

Alcohol and fibrogenesis. Keywords Mesh Terms:

KEYWORDS: Liver Cirrhosis, Alcoholic

MESH TERMS: physiopathology

Chemical & Substance for Abstract: Alcohol and fibrogenesis. Information

Substance Name: Collagen

Registry Number: 9007-34-5

Grant and Affiliation Information for Alcohol and fibrogenesis.

AFFILIATION: Alcohol Research and Treatment Center, Bronx VA Medical Center, New York.

Country: ENGLAND

AGENCY: United States NIAAA

GRANT: AA03508

ACRONYM: AA

MEDLINETA: Alcohol Alcohol Suppl

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