Albuminuria as risk factor for initiation and progression of carotid atherosclerosis in non-diabetic persons: the Tromsø Study.

Albuminuria as risk factor for initiation and progression of carotid atherosclerosis in non-diabetic persons: the Tromsø Study. Research Abstract Details 

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Albuminuria as risk factor for initiation and progression of carotid atherosclerosis in non-diabetic persons: the Tromsø Study. Abstract Text:

Lone ,Trond Jenssen,Stein Harald Johnsen,Ellisiv B Mathiesen,Ivar Heuch,Oddmund Joakimsen,Einar Fosse,Bjarne K Jacobsen,Lone ,Trond Jenssen,Stein Harald Johnsen,Ellisiv B Mathiesen,Ivar Heuch,Oddmund Joakimsen,Einar Fosse,Bjarne K Jacobsen,

AIMS: High levels of microalbuminuria have been associated with severe atherosclerosis. In this prospective, population-based study, we examined whether urinary albumin-to-creatinine-ratios (ACR) in the lower range were associated with the initiation and progression of atherosclerosis. METHODS AND RESULTS: Carotid ultrasonography and measurements of ACR, fibrinogen, monocytes, white cell count, and well-established cardiovascular risk factors were performed in 4037 non-diabetic subjects, 2203 without, and 1834 with pre-existing plaques at baseline. After 7 years new ultrasound measurements were performed. In subjects without pre-existing plaques, 884 had developed at least one plaque during follow-up. Baseline ACR was significantly related to the area of the novel plaques (P for linear trend = 0.009 over the baseline ACR quartiles, after multiple adjustments). The relationship with ACR was clearly modified by fibrinogen (P = 0.001, for the interaction ACR x fibrinogen). Subjects with high levels of both ACR and fibrinogen developed plaques with the largest area. In subjects with pre-existing plaques, ACR was related to plaque-progression (P for linear trend = 0.026, after multiple adjustments). In these individuals, the interaction between fibrinogen and ACR on plaque-growth appeared only in those with minimal atherosclerosis at baseline. CONCLUSION: ACR is positively related to plaque-initiation and plaque-growth. This relationship is substantially modified by fibrinogen in previously plaque-free subjects.

Albuminuria as risk factor for initiation and progression of carotid atherosclerosis in non-diabetic persons: the Tromsø Study. Publishing Authors By Initials

L ,T Jenssen,SH Johnsen,EB Mathiesen,I Heuch,O Joakimsen,E Fosse,BK Jacobsen,L ,T Jenssen,SH Johnsen,EB Mathiesen,I Heuch,O Joakimsen,E Fosse,BK Jacobsen,

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Albuminuria as risk factor for initiation and progression of carotid atherosclerosis in non-diabetic persons: the Tromsø Study. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: European heart journal

VOLUME: 28

Page Numbers: 363-9

Journal Abbreviation: Eur. Heart J.

ISSN: 0195-668X

DAY: 28

MONTH: 11

YEAR: 2006

Albuminuria as risk factor for initiation and progression of carotid atherosclerosis in non-diabetic persons: the Tromsø Study. Information

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LANGUAGE: eng

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AFFILIATION: Institute of Community Medicine, University of Tromsø, N-9037 Tromsø, Norway. lone.jorgensen@ism.uit.no

Country: England

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MEDLINETA: Eur Heart J

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