Alanine scan of [L-Dap(2)]ramoplanin A2 aglycon: assessment of the importance of each residue.

Alanine scan of [L-Dap(2)]ramoplanin A2 aglycon: assessment of the importance of each residue. Research Abstract Details 

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Alanine scan of [L-Dap(2)]ramoplanin A2 aglycon: assessment of the importance of each residue. Abstract Text:

Joonwoo Nam,Dongwoo Shin,Yosup Rew,Dale L Boger,

In efforts that define the importance of each residue and that identify key regions of the molecule, an alanine scan of the ramoplanin A2 aglycon, a potent antibiotic that inhibits bacterial cell wall biosynthesis, is detailed. As a consequence of both its increased stability (lactam vs lactone) and its "relative" ease of synthesis, the alanine scan was conducted on [Dap2]ramoplanin A2 aglycon, which possesses antimicrobial activity equal to or slightly more potent than that of ramoplanin A2 or its aglycon. Thus, 14 key analogues of the ramoplanin A2 aglycon, representing a scan of residues 3-13, 15, and 17, were prepared enlisting a convergent solution-phase total synthesis that consolidated the effort to a manageable level. The antimicrobial activity of the resulting library of analogues provides insight into the importance and potential role of each residue of this complex glycopeptide antibiotic.

Alanine scan of [L-Dap(2)]ramoplanin A2 aglycon: assessment of the importance of each residue. Publishing Authors By Initials

J Nam,D Shin,Y Rew,DL Boger,

For similar peptides: peptide library research abstracts see: peptides: peptide library research

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Alanine scan of [L-Dap(2)]ramoplanin A2 aglycon: assessment of the importance of each residue. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Journal of the American Chemical Society

VOLUME: 129

Page Numbers: 8747-55

Journal Abbreviation: J. Am. Chem. Soc.

ISSN: 0002-7863

DAY: 26

MONTH: 06

YEAR: 2007

Alanine scan of [L-Dap(2)]ramoplanin A2 aglycon: assessment of the importance of each residue. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7503056

Alanine scan of [L-Dap(2)]ramoplanin A2 aglycon: assessment of the importance of each residue. Keywords Mesh Terms:

KEYWORDS: Peptide Library

MESH TERMS: genetics

Chemical & Substance for Abstract: Alanine scan of [L-Dap(2)]ramoplanin A2 aglycon: assessment of the importance of each residue. Information

Substance Name: Alanine

Registry Number: 56-41-7

Grant and Affiliation Information for Alanine scan of [L-Dap(2)]ramoplanin A2 aglycon: assessment of the importance of each residue.

AFFILIATION: Department of Chemistry and the Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA.

Country: United States

AGENCY: United States NCI

GRANT: CA41101

ACRONYM: CA

MEDLINETA: J Am Chem Soc

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