Akt is involved in the inhibition of cell proliferation by EGF.

Akt is involved in the inhibition of cell proliferation by EGF. Research Abstract Details 

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Akt is involved in the inhibition of cell proliferation by EGF. Abstract Text:

Soung Hoo Jeon,Woo-Jeong Jeong,Jae-Young Cho,Kee-Ho Lee,Kang-Yell Choi,Soung Hoo Jeon,Woo-Jeong Jeong,Jae-Young Cho,Kee-Ho Lee,Kang-Yell Choi,

Axin is a negative regulator of the Wnt/beta-catenin pathway and is involved in the regulation of axis formation and proliferation. Involvement of Axin in the regulation of other signaling pathways is poorly understood. In this study, we investigated the involvement of Akt in growth regulation by Axin in L929 fibroblasts stimulated by EGF. Akt activity was increased by EGF treatment and Ras activation, respectively. Both the EGF- and Ras-induced Akt activations were abolished by Axin induction, as revealed by both Western blot and immunocytochemical analyses. The proliferation and Akt activation induced by EGF were decreased by Axin induction, and the effects of EGF were abolished by treatment of an Akt-specific inhibitor. Therefore, Axin inhibits EGF-induced proliferation of L929 fibroblasts by blocking Akt activation.

Akt is involved in the inhibition of cell proliferation by EGF. Publishing Authors By Initials

SH Jeon,WJ Jeong,JY Cho,KH Lee,KY Choi,SH Jeon,WJ Jeong,JY Cho,KH Lee,KY Choi,

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Akt is involved in the inhibition of cell proliferation by EGF. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Experimental & molecular medicine

VOLUME: 39

Page Numbers: 491-8

Journal Abbreviation: Exp. Mol. Med.

ISSN: 1226-3613

DAY: 31

MONTH: Aug

YEAR: 2007

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LANGUAGE: eng

NlmUniqueID: 9607880

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AFFILIATION: Department of Biotechnology, Yonsei University, Seoul 120-752, Korea.

Country: Korea (South)

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MEDLINETA: Exp Mol Med

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