[Akatinol memantin in Alzheimer's disease: clinico-immunological correlates]

[Akatinol memantin in Alzheimer's disease: clinico-immunological correlates] Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

[Akatinol memantin in Alzheimer's disease: clinico-immunological correlates] Abstract Text:

L V Androsova,N D Selezneva,

16 patients with Alzheimer's disease were treated with akatinol memantine. The levels of production of interleukin-1 (IL-1) in lymphocyte culture were evaluated both before and after the treatment that lasted for 2-4.5 months. Before the therapy a significant (p < 0.05) increase in the production of IL-1 was observed in patients with mild and moderate dementia, with early onset of the disease and with the duration of the disease up to 9 years as compared with a control group (24 healthy individuals). After the treatment the production of IL-1 was decreased in patients with moderate dementia, with early onset, and with hereditary form of the disease. Decrease of the level of IL-1 production after the treatment corresponded to improvement of the cognitive functions of the patient. In cases of unsatisfactory treatment (without any improvement of a clinical state) IL-1 production was at higher levels (p < 0.05) as compared with the control values. It is suggested that initial high level of IL-1 production could serve as a predictor of efficiency of therapy with akatinol memantine in patients with early onset of Alzheimer's disease.

[Akatinol memantin in Alzheimer's disease: clinico-immunological correlates] Publishing Authors By Initials

LV Androsova,ND Selezneva,

For similar behavioral disciplines and activities: behavioral sciences: psychopathology research abstracts see: behavioral disciplines and activities: behavioral sciences: psychopathology research

PUBMED ID PMID:

MEDLINE DATE:

[Akatinol memantin in Alzheimer's disease: clinico-immunological correlates] Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Zhurnal nevrologii i psikhiatrii imeni S.S. Korsak

VOLUME: 100

Page Numbers: 36-8

Journal Abbreviation:

ISSN: 1997-7298

DAY: 31

MONTH: 03

YEAR: 2000

[Akatinol memantin in Alzheimer's disease: clinico-immunological correlates] Information

Number of References:

LANGUAGE: rus

NlmUniqueID: 9712194

[Akatinol memantin in Alzheimer's disease: clinico-immunological correlates] Keywords Mesh Terms:

KEYWORDS: Psychopathology

MESH TERMS: therapeutic use

Chemical & Substance for Abstract: [Akatinol memantin in Alzheimer's disease: clinico-immunological correlates] Information

Substance Name: Memantine

Registry Number: 19982-08-2

Grant and Affiliation Information for [Akatinol memantin in Alzheimer's disease: clinico-immunological correlates]

AFFILIATION:

Country: RUSSIA

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Zh Nevrol Psikhiatr Im S S Kor

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Akatinol memantin in Alzheimer's disease: clinico-immunological correlates Related Publications

• [Akatinol memantin in Alzheimer's disease: clinico-immunological correlates]
• [ApoE genotype and efficacy of neurotrophic and cholinergic therapy in Alzheimer's disease]
• [Creation of a favorable psychological climate in the family]
• [Electronmicroscopical study of cell membranes in the allantoic epithelium]
• [Frequency of mutagen-induced sister chromatid exchanges in the course of 3 cell cycles]
• [Neuropsychological evaluation of long-term therapy of Alzheimer's disease using different cerebrolysin dosages]
• [System of natural killer lymphocytes in Alzheimer's type dementias]
• [Temperature sensitivity of neoplastic cells and its study using microbiological models]
• [Use of 5-bromodeoxyuridine for determining the duration of cell cycle phases]