Ajuba negatively regulates the Wnt signaling pathway by promoting GSK-3beta-mediated phosphorylation of beta-catenin.

Ajuba negatively regulates the Wnt signaling pathway by promoting GSK-3beta-mediated phosphorylation of beta-catenin. Research Abstract Details 

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Ajuba negatively regulates the Wnt signaling pathway by promoting GSK-3beta-mediated phosphorylation of beta-catenin. Abstract Text:

K Haraguchi,M Ohsugi,Y Abe,K Semba,T Akiyama,T Yamamoto,K Haraguchi,M Ohsugi,Y Abe,K Semba,T Akiyama,T Yamamoto,

The Wnt signaling pathway is essential for embryonic development and carcinogenesis. Upon Wnt stimulation, beta-catenin is stabilized and associates with T-cell factor or lymphoid enhancing factor, thereby activating transcription of target genes. In the absence of Wnt stimulation, the level of beta-catenin is reduced via glycogen synthase kinase (GSK)-3beta-mediated phosphorylation and subsequent proteasome-dependent degradation. Here, we report the identification of Ajuba as a negative regulator of the Wnt signaling pathway. Ajuba is a member of LIM domain-containing proteins that contribute to cell fate determination and regulate cell proliferation and differentiation. We found that enforced expression of Ajuba destabilized beta-catenin and suppressed target gene expression. Ajuba promoted GSK-3beta-mediated phosphorylation of beta-catenin by reinforcing the association between beta-catenin and GSK-3beta. Furthermore, Wnt stimulation induced both accumulation of beta-catenin and destabilization of Ajuba. Our findings suggest that Ajuba is important for regulation of the Wnt signaling pathway.

Ajuba negatively regulates the Wnt signaling pathway by promoting GSK-3beta-mediated phosphorylation of beta-catenin. Publishing Authors By Initials

K Haraguchi,M Ohsugi,Y Abe,K Semba,T Akiyama,T Yamamoto,K Haraguchi,M Ohsugi,Y Abe,K Semba,T Akiyama,T Yamamoto,

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Ajuba negatively regulates the Wnt signaling pathway by promoting GSK-3beta-mediated phosphorylation of beta-catenin. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Oncogene

VOLUME: 27

Page Numbers: 274-84

Journal Abbreviation: Oncogene

ISSN: 1476-5594

DAY: 9

MONTH: 07

YEAR: 2007

Ajuba negatively regulates the Wnt signaling pathway by promoting GSK-3beta-mediated phosphorylation of beta-catenin. Information

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LANGUAGE: eng

NlmUniqueID: 8711562

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Grant and Affiliation Information for Ajuba negatively regulates the Wnt signaling pathway by promoting GSK-3beta-mediated phosphorylation of beta-catenin.

AFFILIATION: Division of Oncology, Institute of Medical Science, University of Tokyo, Tokyo, Japan.

Country: England

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MEDLINETA: Oncogene

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