Airway eosinophils: allergic inflammation recruited professional antigen-presenting cells.

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Airway eosinophils: allergic inflammation recruited professional antigen-presenting cells. Abstract Text:

Hai-Bin Wang,Ionita Ghiran,Klaus Matthaei,Peter F Weller,Hai-Bin Wang,Ionita Ghiran,Klaus Matthaei,Peter F Weller,Hai-Bin Wang,Ionita Ghiran,Klaus Matthaei,Peter F Weller,

The capacity of airway eosinophils, potentially pertinent to allergic diseases of the upper and lower airways, to function as professional APCs, those specifically able to elicit responses from unprimed, Ag-naive CD4(+) T cells has been uncertain. We investigated whether airway eosinophils are capable of initiating naive T cell responses in vivo. Eosinophils, isolated free of other APCs from the spleens of IL-5 transgenic mice, following culture with GM-CSF expressed MHC class II and the costimulatory proteins, CD40, CD80, and CD86. Eosinophils, incubated with OVA Ag in vitro, were instilled intratracheally into wild-type recipient mice that adoptively received i.v. infusions of OVA Ag-specific CD4(+) T cells from OVA TCR transgenic mice. OVA-exposed eosinophils elicited activation (CD69 expression), proliferation (BrdU incorporation), and IL-4, but not IFN-gamma, cytokine production by OVA-specific CD4(+) T cells in paratracheal lymph nodes (LN). Exposure of eosinophils to lysosomotropic NH(4)Cl, which inhibits Ag processing, blocked each of these eosinophil-mediated activation responses of CD4(+) T cells. By three-color fluorescence microscopy, OVA Ag-loaded eosinophil APCs were physically interacting with naive OVA-specific CD4(+) T cells in paratracheal LN after eosinophil airway instillation. Thus, recruited luminal airway eosinophils are distinct allergic "inflammatory" professional APCs able to activate primary CD4(+) T cell responses in regional LNs.

Airway eosinophils: allergic inflammation recruited professional antigen-presenting cells. Publishing Authors By Initials

HB Wang,I Ghiran,K Matthaei,PF Weller,HB Wang,I Ghiran,K Matthaei,PF Weller,HB Wang,I Ghiran,K Matthaei,PF Weller,

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Airway eosinophils: allergic inflammation recruited professional antigen-presenting cells. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of immunology (Baltimore, Md. : 1950)

VOLUME: 179

Page Numbers: 7585-92

Journal Abbreviation: J. Immunol.

ISSN: 0022-1767

DAY: 1

MONTH: Dec

YEAR: 2007

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LANGUAGE: eng

NlmUniqueID: 2985117

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AFFILIATION: Divisions of Allergy and Inflammation and Infectious Diseases, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115.

Country: United States

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MEDLINETA: J Immunol

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