Air pollution alters brain and pituitary endothelin-1 and inducible nitric oxide synthase gene expression.

Air pollution alters brain and pituitary endothelin-1 and inducible nitric oxide synthase gene expression. Research Abstract Details 

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Air pollution alters brain and pituitary endothelin-1 and inducible nitric oxide synthase gene expression. Abstract Text:

Errol M Thomson,Prem Kumarathasan,Lilian ,Renaud Vincent,

Recent work suggests that air pollution is a risk factor for cerebrovascular and neurodegenerative disease. Effects of inhaled pollutants on the production of vasoactive factors such as endothelin (ET) and nitric oxide (NO) in the brain may be relevant to disease pathogenesis. Inhaled pollutants increase circulating levels of ET-1 and ET-3, and the pituitary is a potential source of plasma ET, but the effects of pollutants on the expression of ET and NO synthase genes in the brain and pituitary are not known. In the present study, Fischer-344 rats were exposed by nose-only inhalation to particles (0, 5, 50mg/m3 EHC-93), ozone (0, 0.4, 0.8 ppm), or combinations of particles and ozone for 4 h. Real-time reverse transcription polymerase chain reaction was used to measure mRNA levels in the cerebral hemisphere and pituitary 0 and 24 h post-exposure. Ozone inhalation significantly increased preproET-1 but decreased preproET-3 mRNAs in the cerebral hemisphere, while increasing mRNA levels of preproET-1, preproET-3, and the ET-converting enzyme (ECE)-1 in the pituitary. Inducible NO synthase (iNOS) was initially decreased in the cerebral hemisphere after ozone inhalation, but increased 24 h post-exposure. Particles decreased tumour necrosis factor (TNF)-alpha mRNA in the cerebral hemisphere, and both particles and ozone decreased TNF-alpha mRNA in the pituitary. Our results show that ozone and particulate matter rapidly modulate the expression of genes involved in key vasoregulatory pathways in the brain and pituitary, substantiating the notion that inhaled pollutants induce cerebrovascular effects.

Air pollution alters brain and pituitary endothelin-1 and inducible nitric oxide synthase gene expression. Publishing Authors By Initials

EM Thomson,P Kumarathasan,L ,R Vincent,

For similar peptides: intercellular signaling peptides and proteins: cytokines: monokines: tumor necrosis factor-alpha research abstracts see: peptides: intercellular signaling peptides and proteins: cytokines: monokines: tumor necrosis factor-alpha research

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Air pollution alters brain and pituitary endothelin-1 and inducible nitric oxide synthase gene expression. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Environmental research

VOLUME: 105

Page Numbers: 224-33

Journal Abbreviation: Environ. Res.

ISSN: 0013-9351

DAY: 30

MONTH: 07

YEAR: 2007

Air pollution alters brain and pituitary endothelin-1 and inducible nitric oxide synthase gene expression. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 147621

Air pollution alters brain and pituitary endothelin-1 and inducible nitric oxide synthase gene expression. Keywords Mesh Terms:

KEYWORDS: Tumor Necrosis Factor-alpha

MESH TERMS: genetics

Chemical & Substance for Abstract: Air pollution alters brain and pituitary endothelin-1 and inducible nitric oxide synthase gene expression. Information

Substance Name: Nos2 protein, rat

Registry Number: EC 1.14.13.39

Grant and Affiliation Information for Air pollution alters brain and pituitary endothelin-1 and inducible nitric oxide synthase gene expression.

AFFILIATION: Healthy Environments and Consumer Safety Branch, Health Canada, Ottawa, Ont., Canada K1A 0K9.

Country: United States

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MEDLINETA: Environ Res

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