AI-2-dependent gene regulation in Staphylococcus epidermidis.

AI-2-dependent gene regulation in Staphylococcus epidermidis. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

AI-2-dependent gene regulation in Staphylococcus epidermidis. Abstract Text:

Min Li,Amer E Villaruz,Viveka Vadyvaloo,Daniel E Sturdevant,Michael Otto,

BACKGROUND: Autoinducer 2 (AI-2), a widespread by-product of the LuxS-catalyzed S-ribosylhomocysteine cleavage reaction in the activated methyl cycle, has been suggested to serve as an intra- and interspecies signaling molecule, but in many bacteria AI-2 control of gene expression is not completely understood. Particularly, we have a lack of knowledge about AI-2 signaling in the important human pathogens Staphylococcus aureus and S. epidermidis. RESULTS: To determine the role of LuxS and AI-2 in S. epidermidis, we analyzed genome-wide changes in gene expression in an S. epidermidis luxS mutant and after addition of AI-2 synthesized by over-expressed S. epidermidis Pfs and LuxS enzymes. Genes under AI-2 control included mostly genes involved in sugar, nucleotide, amino acid, and nitrogen metabolism, but also virulence-associated genes coding for lipase and bacterial apoptosis proteins. In addition, we demonstrate by liquid chromatography/mass-spectrometry of culture filtrates that the pro-inflammatory phenol-soluble modulin (PSM) peptides, key virulence factors of S. epidermidis, are under luxS/AI-2 control. CONCLUSION: Our results provide a detailed molecular basis for the role of LuxS in S. epidermidis virulence and suggest a signaling function for AI-2 in this bacterium.

AI-2-dependent gene regulation in Staphylococcus epidermidis. Publishing Authors By Initials

M Li,AE Villaruz,V Vadyvaloo,DE Sturdevant,M Otto,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

AI-2-dependent gene regulation in Staphylococcus epidermidis. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Intr

Journal: BMC microbiology

VOLUME: 8

Page Numbers: 4

Journal Abbreviation: BMC Microbiol.

ISSN: 1471-2180

DAY: 8

MONTH: 01

YEAR: 2008

AI-2-dependent gene regulation in Staphylococcus epidermidis. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 100966981

AI-2-dependent gene regulation in Staphylococcus epidermidis. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: AI-2-dependent gene regulation in Staphylococcus epidermidis. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for AI-2-dependent gene regulation in Staphylococcus epidermidis.

AFFILIATION: Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, The National Institutes of Health, Hamilton, MT 59840, USA. limin2@niaid.nih.gov

Country: England

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: BMC Microbiol

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

AI-2-dependent gene regulation in Staphylococcus epidermidis Related Publications

• 553.
• A Comparison of the PACER versus the Mile Run/Walk Test for the Estimation of Aerobic Capacity of Middle School Children: 2218: Board #131 June 1 9:00 AM - 10:30 AM.
• Antibodies to block Staph virulence.
• CZE for the speciation of arsenic in aqueous soil extracts.
• Cognitive and behavioral processes applied during physical activity adoption and maintenance: 1952: board #22 may 31 3:30 PM - 5:00 PM.
• Community-associated MRSA: a dangerous epidemic.
• Effects of averaging data series on the electroencephalographic response to noxious visceral stimulation in isoflurane-anaesthetized dogs.
• Estimating a binary character's effect on speciation and extinction.
• Heartworm in dogs.
• Identification of novel cytolytic peptides as key virulence determinants for community-associated MRSA.
• Implants splinted to natural teeth.
• Inhibition of hepatitis C replicon RNA synthesis by beta-D-2'-deoxy-2'-fluoro-2'-C-methylcytidine: a specific inhibitor of hepatitis C virus replication.
• Integrated optical microcavities for enhanced evanescent-wave spectroscopy.
• Introduction and Overview: 201: 1:00 PM-1:05 PM.
• Learning on the Web. Case 8: systolic murmur in an asymptomatic 70 year old man.
• Management of the unknown primary carcinoma: Long-term follow-up on a negative PET scan and negative panendoscopy.
• Sensor based on an integrated optical microcavity.
• Spontaneous ventral urethral fistula in a young diabetic man: a case report.
• Survey of the seroprevalence of brucellosis in ruminants in Tajikistan.
• Temporisation during implant treatment (Part 1).
• The Affects of Acute Static Stretching on Anaerobic Performance of Recreational Softball Players: 2572: Board #119 June 2 9:30 AM - 11:00 AM.
• The antimicrobial peptide-sensing system aps of Staphylococcus aureus.
• The cardiovascular response to incremental, submaximal exercise in patients on cardioselective Beta blockers: 2387: board #66 june 1 2:00 PM -3:30 PM.
• The effects of pre-swim hyperventilation on free style swim performance: 1981: board #51 may 31 2:00 PM .3:30 PM.
• The evolutionary consequences of polyploidy.
• Treatment planning options.
• Valvular heart disease: focus on women.
• [Not Available.]
• [Reprocessing cystoscopes in urology. Guideline compliance in hospitals and private practices in Frankfurt/M, Germany in 2005/2006]
• [Transarterial chemoembolization (TACE) of the hepatocellular carcinoma (HCC) in patients with portal vein thrombosis--experiences]