Ah receptor, a novel ligand-activated transcription factor.

Ah receptor, a novel ligand-activated transcription factor. Research Abstract Details 

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Ah receptor, a novel ligand-activated transcription factor. Abstract Text:

K Sogawa,Y Fujii-Kuriyama,

The aryl hydrocarbon receptor (AhR) is widely distributed in vertebrates and is known to be involved in metabolism of xenobiotics including man-made chemicals, most of which act as a ligand for the receptor, although no endogenous ligand has yet been known. Upon binding a ligand, the receptor is activated to translocate to the nuclei, and during the nuclear translocation process, it is dissociated from the 90 kDa heat shock protein (Hsp90) to form a heterodimer with Arnt (Ah receptor nuclear translocator). The heterodimer complex binds a DNA response element termed xenobiotic responsive element (XRE) localized upstream of the target genes of many drug-metabolizing enzymes including cytochrome P4501A1 and glutathione S-transferase to activate their transcription. Recent cDNA cloning has revealed that the AhR, like Arnt, possesses characteristic structural motifs of basic helix-loop-helix and PAS domains responsible for DNA recognition, heterodimerization, and ligand binding, and functions as a novel receptor-type transcription factor.

Ah receptor, a novel ligand-activated transcription factor. Publishing Authors By Initials

K Sogawa,Y Fujii-Kuriyama,

For similar proteins: transcription factors research abstracts see: proteins: transcription factors research

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Ah receptor, a novel ligand-activated transcription factor. Journal Published:

PUBLICATION TYPE: Review

Journal: Journal of biochemistry

VOLUME: 122

Page Numbers: 1075-9

Journal Abbreviation: J. Biochem.

ISSN: 0021-924X

DAY: 19

MONTH: Dec

YEAR: 1997

Ah receptor, a novel ligand-activated transcription factor. Information

Number of References: 56

LANGUAGE: eng

NlmUniqueID: 376600

Ah receptor, a novel ligand-activated transcription factor. Keywords Mesh Terms:

KEYWORDS: Transcription Factors

MESH TERMS: physiology

Chemical & Substance for Abstract: Ah receptor, a novel ligand-activated transcription factor. Information

Substance Name: Transcription Factors

Registry Number: 0

Grant and Affiliation Information for Ah receptor, a novel ligand-activated transcription factor.

AFFILIATION: Department of Chemistry, Graduate School of Science, Tohoku University, Sendai. sogawa@mail.cc.tohoku.ac.jp

Country: JAPAN

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MEDLINETA: J Biochem

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