Agrin is required for posterior development and motor axon outgrowth and branching in embryonic zebrafish.

Agrin is required for posterior development and motor axon outgrowth and branching in embryonic zebrafish. Research Abstract Details 

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Agrin is required for posterior development and motor axon outgrowth and branching in embryonic zebrafish. Abstract Text:

Min Jung Kim,I-Hsuan Liu,Yuanquan Song,Ju-Ahng Lee,Willi Halfter,Rita J Balice-Gordon,Elwood Linney,Gregory J Cole,

Although recent studies have extended our understanding of agrin's function during development, its function in the central nervous system (CNS) is not clearly understood. To address this question, zebrafish agrin was identified and characterized. Zebrafish agrin is expressed in the developing CNS and in nonneural structures such as somites and notochord. In agrin morphant embryos, acetylcholine receptor (AChR) cluster number and size on muscle fibers at the choice point were unaffected, whereas AChR clusters on muscle fibers in the dorsal and ventral regions of the myotome were reduced or absent. Defects in the axon outgrowth by primary motor neurons, subpopulations of branchiomotor neurons, and Rohon-Beard sensory neurons were also observed, which included truncation of axons and increased branching of motor axons. Moreover, agrin morphants exhibit significantly inhibited tail development in a dose-dependent manner, as well as defects in the formation of the midbrain-hindbrain boundary and reduced size of eyes and otic vesicles. Together these results show that agrin plays an important role in both peripheral and CNS development and also modulates posterior development in zebrafish.

Agrin is required for posterior development and motor axon outgrowth and branching in embryonic zebrafish. Publishing Authors By Initials

MJ Kim,IH Liu,Y Song,JA Lee,W Halfter,RJ Balice-Gordon,E Linney,GJ Cole,

For similar proteins: fish proteins: zebrafish proteins research abstracts see: proteins: fish proteins: zebrafish proteins research

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Agrin is required for posterior development and motor axon outgrowth and branching in embryonic zebrafish. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Glycobiology

VOLUME: 17

Page Numbers: 231-47

Journal Abbreviation: Glycobiology

ISSN: 0959-6658

DAY: 16

MONTH: 11

YEAR: 2006

Agrin is required for posterior development and motor axon outgrowth and branching in embryonic zebrafish. Information

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LANGUAGE: eng

NlmUniqueID: 9104124

Agrin is required for posterior development and motor axon outgrowth and branching in embryonic zebrafish. Keywords Mesh Terms:

KEYWORDS: Zebrafish Proteins

MESH TERMS: physiology

Chemical & Substance for Abstract: Agrin is required for posterior development and motor axon outgrowth and branching in embryonic zebrafish. Information

Substance Name: Zebrafish Proteins

Registry Number: 0

Grant and Affiliation Information for Agrin is required for posterior development and motor axon outgrowth and branching in embryonic zebrafish.

AFFILIATION: Laboratory of Molecular Genetics, NICHD, NIH, Bethesda, MD 20892, USA.

Country: England

AGENCY: United States NINDS

GRANT: NS 33981

ACRONYM: NS

MEDLINETA: Glycobiology

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