Aging, and crosslinking in mammlian collagen.

Aging, and crosslinking in mammlian collagen. Research Abstract Details 

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Aging, and crosslinking in mammlian collagen. Abstract Text:

The amount and type of borohydride-reducible crosslinks in collagen have been examined as a function of animal age. In a variety of bovine, canine and human tissues the level of redicible crosslinks decreases with time and the ratios of individual compounds change. There is both tissue and species specificity in the extent of these changes. A decrease in the level of reducible crosslinks correlates with the cessation of growth. Loss of reducible crosslinks does not imply a small total number of crosslinks since physical changes with age imply the opposite. We conclude that reducible crosslinks are converted to a stable nonreducible state and the persistence of low levels of reducible crosslinks may be indicative of a low level of turnover in the tissue. Changes in ratios of reducible crosslinks are of doubtful functioal significance and may simply reflect variation in post-translational modification of lysine residues.

Aging, and crosslinking in mammlian collagen. Publishing Authors By Initials

For similar musculoskeletal system: tendons research abstracts see: musculoskeletal system: tendons research

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Aging, and crosslinking in mammlian collagen. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Experimental aging research

VOLUME: 3

Page Numbers: 87-105

Journal Abbreviation:

ISSN: 0361-073X

DAY: 25

MONTH: Mar

YEAR: 1977

Aging, and crosslinking in mammlian collagen. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7603335

Aging, and crosslinking in mammlian collagen. Keywords Mesh Terms:

KEYWORDS: Tendons

MESH TERMS: analogs & derivatives

Chemical & Substance for Abstract: Aging, and crosslinking in mammlian collagen. Information

Substance Name: Collagen

Registry Number: 9007-34-5

Grant and Affiliation Information for Aging, and crosslinking in mammlian collagen.

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Country: UNITED STATES

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MEDLINETA: Exp Aging Res

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