Aging alters circadian and light-induced expression of clock genes in golden hamsters.

Aging alters circadian and light-induced expression of clock genes in golden hamsters. Research Abstract Details 

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Aging alters circadian and light-induced expression of clock genes in golden hamsters. Abstract Text:

Daniel E Kolker,Hiroo Fukuyama,David S Huang,Joseph S Takahashi,Teresa H Horton,Fred W Turek,

Aging alters numerous aspects of circadian biology, including the amplitude of rhythms generated by the suprachiasmatic nuclei (SCN) of the hypothalamus, the site of the central circadian pacemaker in mammals, and the response of the pacemaker to environmental stimuli such as light. Although previous studies have described molecular correlates of these behavioral changes, to date only 1 study in rats has attempted to determine if there are age-related changes in the expression of genes that comprise the circadian clock itself. We used in situ hybridization to examine the effects of age on the circadian pattern of expression of a subset of the genes that comprise the molecular machinery of the circadian clock in golden hamsters. Here we report that age alters the 24-h expression profile of Clock and its binding partner Bmal1 in the hamster SCN. There is no effect of age on the 24-h profile of either Per1 or Per2 when hamsters are housed in constant darkness. We also found that light pulses, which induce smaller phase shifts in old animals than in young, lead to decreased induction of Per1, but not of Per2, in the SCN of old hamsters.

Aging alters circadian and light-induced expression of clock genes in golden hamsters. Publishing Authors By Initials

DE Kolker,H Fukuyama,DS Huang,JS Takahashi,TH Horton,FW Turek,

For similar proteins: transcription factors research abstracts see: proteins: transcription factors research

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Aging alters circadian and light-induced expression of clock genes in golden hamsters. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Journal of biological rhythms

VOLUME: 18

Page Numbers: 159-69

Journal Abbreviation: J. Biol. Rhythms

ISSN: 0748-7304

DAY: 19

MONTH: Apr

YEAR: 2003

Aging alters circadian and light-induced expression of clock genes in golden hamsters. Information

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LANGUAGE: eng

NlmUniqueID: 8700115

Aging alters circadian and light-induced expression of clock genes in golden hamsters. Keywords Mesh Terms:

KEYWORDS: Transcription Factors

MESH TERMS: genetics

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Substance Name: Transcription Factors

Registry Number: 0

Grant and Affiliation Information for Aging alters circadian and light-induced expression of clock genes in golden hamsters.

AFFILIATION: Department of Neurobiology and Physiology, Northwestern University, Evanston, IL 60208, USA. kolkerd@mail.nih.gov

Country: United States

AGENCY: United States NHLBI

GRANT: R01-HL 59598

ACRONYM: HL

MEDLINETA: J Biol Rhythms

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