Aggressive T-cell large granular lymphocyte leukemia: a case report and review of the literature.

Aggressive T-cell large granular lymphocyte leukemia: a case report and review of the literature. Research Abstract Details 

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Aggressive T-cell large granular lymphocyte leukemia: a case report and review of the literature. Abstract Text:

Todd J Alekshun,Jianguo Tao,Lubomir Sokol,

The majority of patients with T-cell large granular lymphocyte (LGL) leukemia will have an indolent clinical course. Herein, we report a case of an aggressive T-cell LGL leukemia in a previously healthy 42-year-old Caucasian male who presented with acute onset of B-symptoms, hepatosplenomegaly, lymphocytosis, moderate anemia, and thrombocytopenia. Immunophenotypically, the malignant cells co-expressed CD3(+)CD8(+)CD56(+) markers and the T-cell receptor beta (TCR beta) gene demonstrated clonal rearrangement. The patient was treated with an intensive chemotherapeutic regimen (hyper-CVAD) and he achieved a complete remission. A systematic review of all available English literature revealed 12 well-described cases of aggressive T-cell LGL leukemia suggesting that this variant is a new and distinct entity in the spectrum of LGL disorders.

Aggressive T-cell large granular lymphocyte leukemia: a case report and review of the literature. Publishing Authors By Initials

TJ Alekshun,J Tao,L Sokol,

For similar diagnosis: prognosis: treatment outcome research abstracts see: diagnosis: prognosis: treatment outcome research

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Aggressive T-cell large granular lymphocyte leukemia: a case report and review of the literature. Journal Published:

PUBLICATION TYPE: Review

Journal: American journal of hematology

VOLUME: 82

Page Numbers: 481-5

Journal Abbreviation: Am. J. Hematol.

ISSN: 0361-8609

DAY: 26

MONTH: Jun

YEAR: 2007

Aggressive T-cell large granular lymphocyte leukemia: a case report and review of the literature. Information

Number of References: 10

LANGUAGE: eng

NlmUniqueID: 7610369

Aggressive T-cell large granular lymphocyte leukemia: a case report and review of the literature. Keywords Mesh Terms:

KEYWORDS: Treatment Outcome

MESH TERMS: genetics

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Grant and Affiliation Information for Aggressive T-cell large granular lymphocyte leukemia: a case report and review of the literature.

AFFILIATION: Division of Hematology and Oncology, H. Lee Moffitt Cancer Center and Research Institute, University of South Florida, Tampa, Florida, USA.

Country: United States

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MEDLINETA: Am J Hematol

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