Aggressive NK cell leukaemia after splenectomy: association with CD95-resistant memory T-cell proliferation and recalcitrant clinical course of haemophagocytic syndrome.

Aggressive NK cell leukaemia after splenectomy: association with CD95-resistant memory T-cell proliferation and recalcitrant clinical course of haemophagocytic syndrome. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Aggressive NK cell leukaemia after splenectomy: association with CD95-resistant memory T-cell proliferation and recalcitrant clinical course of haemophagocytic syndrome. Abstract Text:

We describe a 44-yr-old Japanese woman with persistent polyclonal T-cell proliferation and recalcitrant clinical course of haemophagocytic syndrome (HPS). T cells bearing alphabeta T-cell receptors (TCR) expressed increased amounts of CD95 and of CD45RO, which are phenotypically memory T cells. The TCR repertoire was broad and diverse. Regardless of CD95 expression, these cells were resistant to CD95-mediated apoptosis. Aggressive natural killer cell leukaemia (ANKL) without an association with Epstein-Barr virus was detected 1 month after therapeutic splenectomy that followed 3 yr of immunosuppressive therapy against HPS. The immunophenotype of these leukaemia cells was CD56, CD16(dim), CD7, CD45RA and they expressed some CD2, CD8 and HLA-DR. Moreover, hyperdiploid clones with complex chromosomal abnormalities were also detected. Latent NK-cell malignancy seemed to cause the CD95-resistant memory T-cell proliferation and splenectomy resulted in overt ANKL progression. There should be careful consideration of the risks versus benefits of splenectomy in HPS, in light of the possibility of fatal leukaemia/lymphoma progression.

Aggressive NK cell leukaemia after splenectomy: association with CD95-resistant memory T-cell proliferation and recalcitrant clinical course of haemophagocytic syndrome. Publishing Authors By Initials

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Aggressive NK cell leukaemia after splenectomy: association with CD95-resistant memory T-cell proliferation and recalcitrant clinical course of haemophagocytic syndrome. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: European journal of haematology

VOLUME: 81

Page Numbers: 236-41

Journal Abbreviation: Eur. J. Haematol.

ISSN: 1600-0609

DAY: 27

MONTH: 05

YEAR: 2008

Aggressive NK cell leukaemia after splenectomy: association with CD95-resistant memory T-cell proliferation and recalcitrant clinical course of haemophagocytic syndrome. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8703985

Aggressive NK cell leukaemia after splenectomy: association with CD95-resistant memory T-cell proliferation and recalcitrant clinical course of haemophagocytic syndrome. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Aggressive NK cell leukaemia after splenectomy: association with CD95-resistant memory T-cell proliferation and recalcitrant clinical course of haemophagocytic syndrome. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Aggressive NK cell leukaemia after splenectomy: association with CD95-resistant memory T-cell proliferation and recalcitrant clinical course of haemophagocytic syndrome.

AFFILIATION: Department of Haematology and Immunology, Kagoshima University Hospital, Kagoshima; and Division of Host response, Center for Chronic Viral Diseases, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.

Country: Denmark

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Eur J Haematol

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Aggressive NK cell leukaemia after splenectomy: association with CD95-resistant memory T-cell proliferation and recalcitrant clinical course of haemophagocytic syndrome Related Publications

• Aberrant DNA methylation of imprinted loci in sperm from oligospermic patients.
• Aggressive NK cell leukaemia after splenectomy: association with CD95-resistant memory T-cell proliferation and recalcitrant clinical course of haemophagocytic syndrome.
• Clinical manifestations of human T lymphotropic virus type I-infected patients with systemic lupus erythematosus.
• Correlated oxides: Sliding electrons take charge.
• Environment of tryptophan residues in alpha-lactalbumin.
• Evidence for the role of disulfide bonds in the masking of chromophore groups in bovine kappa-casein.
• Extensive loss of arterial medial smooth muscle cells and mural extracellular matrix in cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy (CARASIL).
• Highly enhanced expression of CD70 on human T-lymphotropic virus type 1-carrying T-cell lines and adult T-cell leukemia cells.
• Kinetic studies on the ES-complex formation of p-hydroxybenzoate hydroxylase using the stopped-flow method.
• L-Alloisocitrate dehydrogenase and oxalosuccinate decarboxylase from a Pseudomonas sp. utilizing L-alloisocitrate.
• Magnetic Control of Crystal Chirality and the Existence of a Large Magneto-Optical Dichroism Effect in CuB2O4.
• Polarization Reversal in Multiferroic TbMnO3 with a Rotating Magnetic Field Direction.
• Potential use of polyamidoamine dendrimer/alpha-cyclodextrin conjugate (generation 3, G3) as a novel carrier for short hairpin RNA-expressing plasmid DNA.
• Properties of the colicin E 2 -induced degradation of deoxyribonucleic acid in Escherichia coli.
• Pseudorotaxane-Like Supramolecular Complex of Coenzyme Q10 with gamma-Cyclodextrin Formed by Solubility Method.
• Purification of prorennin and production of its antibody.
• Recent progress in understanding the diversity of the human ov-serpin/clade B serpin family.
• Split-root study of autoregulation of nodulation in the model legume Lotus japonicus.
• Studies on NADP-+-specific isocitrate dehydrogenase from an extreme thermophile, Thermus flavus AT-62.
• Studies on homoserine dehydrogenase from an extreme thermophile, Thermus flavus AT-62. Partial purification and properties.
• The structure and function of acid proteases. IV. Inactivation of the acid protease from Mucor pusillus by acid protease-specific inhibitors.
• Trastuzumab monotherapy versus combination therapy for treating recurrent breast cancer: time to progression and survival.
• Tryptic digestion of colicin E2 and its active fragment.
• [A comment on the qualification of the visiting nurse: a requirement for a minimum of 2 years in clinical experience]