Aggressive cutaneous squamous cell carcinoma associated with prolonged voriconazole therapy in a renal transplant patient.

Aggressive cutaneous squamous cell carcinoma associated with prolonged voriconazole therapy in a renal transplant patient. Research Abstract Details 

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Aggressive cutaneous squamous cell carcinoma associated with prolonged voriconazole therapy in a renal transplant patient. Abstract Text:

A Vanacker,G ,J Van Dorpe,W E Peetermans,B Maes,

A 69-year-old man, with a history of end-stage renal disease due to polyarteritis nodosa, followed by invasive pulmonary aspergillosis secondary to cyclophosphamide and corticosteroids, received a renal transplant 2 years ago under prophylactic treatment with voriconazole. Because of the severity of the aspergillosis, it was decided to continue voriconazole for a prolonged period. Eighteen months after transplantation, the patient developed a severe facial phototoxic reaction. A few months later, he developed multiple actinic keratoses and a large, rapidly expanding, poorly differentiated squamous cell carcinoma (SCC) with perineural invasion and metastatic lymph nodes, necessitating radical surgery and radiotherapy. Voriconazole therapy has been suggested to be involved in the development of multi-focal invasive SCC when complicated by a phototoxic reaction. Therefore, an alternative antifungal prophylaxis regimen (for instance with posaconazole) should be considered when evaluating patients for solid organ transplantation who are at high risk for the development of cutaneous malignancies.

Aggressive cutaneous squamous cell carcinoma associated with prolonged voriconazole therapy in a renal transplant patient. Publishing Authors By Initials

A Vanacker,G ,J Van Dorpe,WE Peetermans,B Maes,

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Aggressive cutaneous squamous cell carcinoma associated with prolonged voriconazole therapy in a renal transplant patient. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: American journal of transplantation : official jou

VOLUME: 8

Page Numbers: 877-80

Journal Abbreviation: Am. J. Transplant.

ISSN: 1600-6143

DAY: 5

MONTH: 02

YEAR: 2008

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LANGUAGE: eng

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Grant and Affiliation Information for Aggressive cutaneous squamous cell carcinoma associated with prolonged voriconazole therapy in a renal transplant patient.

AFFILIATION: Department of Nephrology, Heilig Hartziekenhuis Roeselare-Menen, B-8800 Roeselare, Belgium.

Country: Denmark

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MEDLINETA: Am J Transplant

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