Aggressive angiomyxoma with t(12;21) and HMGA2 rearrangement: report of a case and review of the literature.

Aggressive angiomyxoma with t(12;21) and HMGA2 rearrangement: report of a case and review of the literature. Research Abstract Details 

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Aggressive angiomyxoma with t(12;21) and HMGA2 rearrangement: report of a case and review of the literature. Abstract Text:

Conventional cytogenetic analysis of an aggressive angiomyxoma of the rectal wall of a 72-year-old woman revealed a translocation between the long arms of chromosomes 12 and 21, with the karyotype 46,XX,t(12;21)(q15;q21.1). Involvement of the HMGA2 gene locus (12q15) was confirmed by fluorescence in situ hybridization using an HMGA2 breakpoint flanking probe set performed on metaphase and interphase cells from an in situ culture of fresh lesional tissue. Karyotypic rearrangements of 12q13 approximately q15 are considered recurrent in aggressive angiomyxoma, although reported in only five previous cases. Translocation partner chromosome 21 is unique to the present case.

Aggressive angiomyxoma with t(12;21) and HMGA2 rearrangement: report of a case and review of the literature. Publishing Authors By Initials

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Aggressive angiomyxoma with t(12;21) and HMGA2 rearrangement: report of a case and review of the literature. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Cancer genetics and cytogenetics

VOLUME: 181

Page Numbers: 119-24

Journal Abbreviation: Cancer Genet. Cytogenet.

ISSN: 0165-4608

DAY: 25

MONTH: Mar

YEAR: 2008

Aggressive angiomyxoma with t(12;21) and HMGA2 rearrangement: report of a case and review of the literature. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Aggressive angiomyxoma with t(12;21) and HMGA2 rearrangement: report of a case and review of the literature.

AFFILIATION: Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 68198-3135.

Country: United States

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MEDLINETA: Cancer Genet Cytogenet

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