Age, sex and early environment contribute to individual differences in nicotine/acetaldehyde-induced behavioral and endocrine responses in rats.

Age, sex and early environment contribute to individual differences in nicotine/acetaldehyde-induced behavioral and endocrine responses in rats. Research Abstract Details 

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Age, sex and early environment contribute to individual differences in nicotine/acetaldehyde-induced behavioral and endocrine responses in rats. Abstract Text:

Minjung K Park,James D Belluzzi,Sun-Ho Han,Junran Cao,Frances M Leslie,

Neonatal handling was used to evaluate the influence of early environment on responses to nicotine. Rats exposed as pups to daily short-term separation from the dam (H) were compared to non-handled (NH) controls. In experiment 1, prepubescent males and females, aged postnatal day (P) 30, were tested for the effect of nicotine/acetaldehyde (NicAc) on open field behavior and plasma corticosterone levels. NicAc induced increases in ambulatory activity and time spent in the center of the field in NH, but not H, males. Drug-induced increases in initial ambulatory activity, but not center time, were also seen in NH and H females. Handling, but not sex, contributed to group differences in plasma corticosterone levels. In experiment 2, NH and H rats were tested for acquisition of NicAc self-administration at three ages, P27-31, P34-38 and P90-94. Age and sex, but not handling, contributed to differences in performance of this task. Whereas males exhibited a decrease in responding with age, females did not. These findings demonstrate that neonatal handling may serve as an experimental model for individual differences in sensitivity to tobacco constituents. Furthermore, the current study indicates that stress reactivity, age and sex may play differential roles in initiating smoking behavior.

Age, sex and early environment contribute to individual differences in nicotine/acetaldehyde-induced behavioral and endocrine responses in rats. Publishing Authors By Initials

MK Park,JD Belluzzi,SH Han,J Cao,FM Leslie,

For similar behavior and behavior mechanisms: behavior: behavioral symptoms: stress, psychological research abstracts see: behavior and behavior mechanisms: behavior: behavioral symptoms: stress, psychological research

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Age, sex and early environment contribute to individual differences in nicotine/acetaldehyde-induced behavioral and endocrine responses in rats. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Pharmacology, biochemistry, and behavior

VOLUME: 86

Page Numbers: 297-305

Journal Abbreviation: Pharmacol. Biochem. Behav.

ISSN: 0091-3057

DAY: 1

MONTH: 12

YEAR: 2006

Age, sex and early environment contribute to individual differences in nicotine/acetaldehyde-induced behavioral and endocrine responses in rats. Information

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LANGUAGE: eng

NlmUniqueID: 367050

Age, sex and early environment contribute to individual differences in nicotine/acetaldehyde-induced behavioral and endocrine responses in rats. Keywords Mesh Terms:

KEYWORDS: Stress, Psychological

MESH TERMS: psychology

Chemical & Substance for Abstract: Age, sex and early environment contribute to individual differences in nicotine/acetaldehyde-induced behavioral and endocrine responses in rats. Information

Substance Name: Acetaldehyde

Registry Number: 75-07-0

Grant and Affiliation Information for Age, sex and early environment contribute to individual differences in nicotine/acetaldehyde-induced behavioral and endocrine responses in rats.

AFFILIATION: Department of Pharmacology, School of Medicine, University of California, Irvine, California 92697, USA.

Country: United States

AGENCY: United States NIDA

GRANT: DA 191938

ACRONYM: DA

MEDLINETA: Pharmacol Biochem Behav

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