Age-related neuronal loss in the submucosal plexus of the colon of Fischer 344 rats.

Age-related neuronal loss in the submucosal plexus of the colon of Fischer 344 rats. Research Abstract Details 

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Age-related neuronal loss in the submucosal plexus of the colon of Fischer 344 rats. Abstract Text:

Robert J Phillips,Julie C Pairitz,Terry L Powley,

The submucosal plexus (SMP) of the large intestine plays important roles in secretion and motility, functions that are compromised in the aged. To determine the effects of aging on intrinsic SMP neurons and their extrinsic inputs, whole mounts from the colon of ad libitum fed virgin male Fischer 344 rats ranging in age from 6 to 27 months were processed to visualize neurons and nerve fibers immunoreactive for either tyrosine hydroxylase (TH-IR) or calcitonin gene-related peptide (CGRP-IR). Significant age-related loss of SMP neurons occurred as early as 12 months of age and progressed in a roughly linear manner with age, dropping, for example, by 38% in the distal colon. In aging rats, the colonic SMP routinely contained markedly swollen TH-IR axons and terminals and exhibited a reduction of ganglionic neuropil, whereas CGRP-IR fibers evidenced only modest axonopathies. These findings point to selective deterioration of the SMP and its extrinsic inputs as one possible mechanism for the age-related decline in large intestinal function evidenced in the elderly.

Age-related neuronal loss in the submucosal plexus of the colon of Fischer 344 rats. Publishing Authors By Initials

RJ Phillips,JC Pairitz,TL Powley,

For similar enzymes and coenzymes: enzymes: oxidoreductases: oxygenases: mixed function oxygenases: tyrosine 3-monooxygenase research abstracts see: enzymes and coenzymes: enzymes: oxidoreductases: oxygenases: mixed function oxygenases: tyrosine 3-monooxygenase research

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Age-related neuronal loss in the submucosal plexus of the colon of Fischer 344 rats. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Neurobiology of aging

VOLUME: 28

Page Numbers: 1124-37

Journal Abbreviation:

ISSN: 1558-1497

DAY: 21

MONTH: 06

YEAR: 2006

Age-related neuronal loss in the submucosal plexus of the colon of Fischer 344 rats. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8100437

Age-related neuronal loss in the submucosal plexus of the colon of Fischer 344 rats. Keywords Mesh Terms:

KEYWORDS: Tyrosine 3-Monooxygenase

MESH TERMS: metabolism

Chemical & Substance for Abstract: Age-related neuronal loss in the submucosal plexus of the colon of Fischer 344 rats. Information

Substance Name: Tyrosine 3-Monooxygenase

Registry Number: EC 1.14.16.2

Grant and Affiliation Information for Age-related neuronal loss in the submucosal plexus of the colon of Fischer 344 rats.

AFFILIATION: Purdue University, Department of Psychological Sciences, West Lafayette, IN 47907-2081, United States. rphillip@psych.purdue.edu <rphillip@psych.purdue.edu>

Country: United States

AGENCY: United States NIDDK

GRANT: DK61317

ACRONYM: DK

MEDLINETA: Neurobiol Aging

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