Age-related impairment of HDL-mediated cholesterol efflux.

Age-related impairment of HDL-mediated cholesterol efflux. Research Abstract Details 

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Age-related impairment of HDL-mediated cholesterol efflux. Abstract Text:

Hicham Berrougui,Maxim Isabelle,Martin Cloutier,Guillaume Grenier,Abdelouahed Khalil,

Our aim in this study was to investigate the effect of aging on the capacity of HDLs to promote reverse cholesterol transport. HDLs were isolated from plasma of young (Y-HDL) and elderly (E-HDL) subjects. HDL-mediated cholesterol efflux was studied using THP-1 and J774 macrophages. Our results show that E-HDLs present a lower capacity to promote cholesterol efflux than Y-HDLs (41.7 +/- 1.4% vs. 49.0 +/- 2.2%, respectively; P = 0.013). Reduction in the HDL-mediated cholesterol efflux capacity with aging was more significant with HDL(3) than HDL(2) (Y-HDL(3), 57.3 +/- 1% vs. E-HDL(3), 50.9 +/- 2%; P = 0.012). Moreover, our results show that ABCA1-mediated cholesterol efflux is the more affected pathway in terms of cholesterol-removing capacity. Interestingly, the composition and structure of HDL revealed a reduction in the phosphatidylcholine-sphingomyelin ratio (E-HDL, 32.7 +/- 2.7 vs. Y-HDL, 40.0 +/- 1.9; P = 0.029) and in the phospholipidic layer membrane fluidity in E-HDL compared with Y-HDL as well as an alteration in the apolipoprotein A-I structure and charge. In conclusion, our results shown that E-HDLs present a reduced capacity to promote cholesterol efflux, principally through the ABCA1 pathway, and this may explain the increase of the incidence of cardiovascular diseases observed during aging.

Age-related impairment of HDL-mediated cholesterol efflux. Publishing Authors By Initials

H Berrougui,M Isabelle,M Cloutier,G Grenier,A Khalil,

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Age-related impairment of HDL-mediated cholesterol efflux. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of lipid research

VOLUME: 48

Page Numbers: 328-36

Journal Abbreviation: J. Lipid Res.

ISSN: 0022-2275

DAY: 8

MONTH: 11

YEAR: 2006

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LANGUAGE: eng

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AFFILIATION: Research Centre on Aging, Orthopaedic Service, University of Sherbrooke, Sherbrooke, Québec, Canada.

Country: United States

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MEDLINETA: J Lipid Res

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