Age-related changes in the response properties of cartwheel cells in rat dorsal cochlear nucleus.

Age-related changes in the response properties of cartwheel cells in rat dorsal cochlear nucleus. Research Abstract Details 

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Age-related changes in the response properties of cartwheel cells in rat dorsal cochlear nucleus. Abstract Text:

Donald M Caspary,Larry F Hughes,Tracy A Schatteman,Jeremy G Turner,

The fusiform cell and deep layers of the dorsal cochlear nucleus (DCN) show neurotransmitter and functional age-related changes suggestive of a downregulation of inhibitory efficacy onto DCN output neurons. Inhibitory circuits implicated in these changes include vertical and D-multipolar cells. Cartwheel cells comprise a large additional population of DCN inhibitory neurons. Cartwheel cells receive excitatory inputs from granule cell parallel fibers and provide a source of glycinergic inhibitory input onto apical dendrites of DCN fusiform cells. The present study compared the response properties from young and aged units meeting cartwheel-cell criteria in anesthetized rats. Single unit recordings from aged cartwheel cells revealed significantly higher thresholds, increased spontaneous activity and significantly altered rate-level functions characterized by hyperexcitability at higher intensities. Aged cartwheel cells showed a significant reduction in off-set suppression. Collectively, these findings suggest a loss of tonic and perhaps response inhibition onto aged DCN cartwheel neurons. These changes likely reflect a compensatory downregulation of synaptic inhibition in response to a loss of excitatory drive from auditory and non-auditory excitatory inputs via granule cells. The impact of increased excitability of cartwheel cells on DCN output neurons is likely to be complex, influenced by loss of glycinergic release and/or subunit receptor changes which would only partially off-set age-related loss of inhibition onto the somata and basal dendrites of fusiform cells.

Age-related changes in the response properties of cartwheel cells in rat dorsal cochlear nucleus. Publishing Authors By Initials

DM Caspary,LF Hughes,TA Schatteman,JG Turner,

For similar animals: chordata: vertebrates: mammals: rodentia: muridae: murinae: rats: rats, sprague-dawley research abstracts see: animals: chordata: vertebrates: mammals: rodentia: muridae: murinae: rats: rats, sprague-dawley research

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Age-related changes in the response properties of cartwheel cells in rat dorsal cochlear nucleus. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Hearing research

VOLUME: 216-217

Page Numbers: 207-15

Journal Abbreviation: Hear. Res.

ISSN: 0378-5955

DAY: 27

MONTH: 04

YEAR: 2006

Age-related changes in the response properties of cartwheel cells in rat dorsal cochlear nucleus. Information

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LANGUAGE: eng

NlmUniqueID: 7900445

Age-related changes in the response properties of cartwheel cells in rat dorsal cochlear nucleus. Keywords Mesh Terms:

KEYWORDS: Rats, Sprague-Dawley

MESH TERMS: physiology

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Grant and Affiliation Information for Age-related changes in the response properties of cartwheel cells in rat dorsal cochlear nucleus.

AFFILIATION: Department of Pharmacology, Southern Illinois University School of Medicine, P.O. Box 19629, Springfield, IL 62794-9629, USA. dcaspary@siumed.edu

Country: Netherlands

AGENCY: United States NIDCD

GRANT: DC 00151

ACRONYM: DC

MEDLINETA: Hear Res

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