Age-related changes in the mechanical properties of the epimysium in skeletal muscles of rats.

Age-related changes in the mechanical properties of the epimysium in skeletal muscles of rats. Research Abstract Details 

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Age-related changes in the mechanical properties of the epimysium in skeletal muscles of rats. Abstract Text:

Yingxin Gao,Tatiana Y Kostrominova,John A Faulkner,Alan S Wineman,

Skeletal muscle is composed of muscle fibers and an extracellular matrix (ECM). The collagen fiber network of the ECM is a major contributor to the passive force of skeletal muscles at high strain. We investigated the effect of aging on the biomechanical and structural properties of epimysium of the tibialis anterior muscles (TBA) of rats to understand the mechanisms responsible for the age-related changes. The biomechanical properties were tested directly in vitro by uniaxial extension of epimysium. The presence of age-related changes in the arrangement and size of the collagen fibrils in the epimysium was examined by scanning electron microscopy (SEM). A mathematical model was subsequently developed based on the structure-function relationships that predicted the compliance of the epimysium. Biomechanically, the epimysium from old rats was much stiffer than that of the young rats. No differences were found in the ultrastructure and thickness of the epimysium or size of the collagen fibrils between young and old rats. The changes in the arrangement and size of the collagen fibrils do not appear to be the principal cause of the increased stiffness of the epimysium from the old rats. Other changes in the structural composition of the epimysium from old rats likely has a strong effect on the increased stiffness. The age-related increase in the stiffness of the epimysium could play an important role in the impaired lateral force transmission in the muscles of the elderly.

Age-related changes in the mechanical properties of the epimysium in skeletal muscles of rats. Publishing Authors By Initials

Y Gao,TY Kostrominova,JA Faulkner,AS Wineman,

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Age-related changes in the mechanical properties of the epimysium in skeletal muscles of rats. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of biomechanics

VOLUME: 41

Page Numbers: 465-9

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ISSN: 0021-9290

DAY: 26

MONTH: 11

YEAR: 2007

Age-related changes in the mechanical properties of the epimysium in skeletal muscles of rats. Information

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LANGUAGE: eng

NlmUniqueID: 157375

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Grant and Affiliation Information for Age-related changes in the mechanical properties of the epimysium in skeletal muscles of rats.

AFFILIATION: Department of Mechanical Engineering, University of Michigan, Ann Arbor, MI 48109-2125, USA.

Country: United States

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MEDLINETA: J Biomech

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