Age-related cardiac disease model of Drosophila.

Age-related cardiac disease model of Drosophila. Research Abstract Details 

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Age-related cardiac disease model of Drosophila. Abstract Text:

Karen Ocorr,Takeshi Akasaka,Rolf Bodmer,

We have begun to study the genetic basis of deterioration of cardiac function in the fruit fly Drosophila melanogaster as an age-related cardiac disease model. For this purpose we have developed heart function assays in Drosophila and found that the fly's cardiac performance, as that of the human heart, deteriorates with age: aging fruit flies exhibit a progressive increase in electrical pacing-induced heart failure as well as in arrhythmias. The insulin receptor and associated pathways have a dramatic and heart-autonomous influence on age-related cardiac performance in flies, suggestive of potentially similar mechanisms in regulating cardiac aging in vertebrates. Compromised KCNQ and K(ATP) ion channel functions also seem to contribute to the decline in heart performance in aging flies, suggesting that the corresponding vertebrate gene functions may similarly decline with age, in addition to their conserved role in protecting against arrhythmias and hypoxia/ischemia, respectively. The fly heart is thus emerging as a promising genetic model for studying the age-dependent decline in organ function.

Age-related cardiac disease model of Drosophila. Publishing Authors By Initials

K Ocorr,T Akasaka,R Bodmer,

For similar cardiovascular diseases: heart diseases research abstracts see: cardiovascular diseases: heart diseases research

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Age-related cardiac disease model of Drosophila. Journal Published:

PUBLICATION TYPE: Review

Journal: Mechanisms of ageing and development

VOLUME: 128

Page Numbers: 112-6

Journal Abbreviation: Mech. Ageing Dev.

ISSN: 0047-6374

DAY: 27

MONTH: 11

YEAR: 2006

Age-related cardiac disease model of Drosophila. Information

Number of References: 28

LANGUAGE: eng

NlmUniqueID: 347227

Age-related cardiac disease model of Drosophila. Keywords Mesh Terms:

KEYWORDS: Heart Diseases

MESH TERMS: physiopathology

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Grant and Affiliation Information for Age-related cardiac disease model of Drosophila.

AFFILIATION: The Burnham Institute for Medical Research, Center for Neuroscience and Aging, 10901 North Torrey Pines Road, La Jolla, CA 92130, USA.

Country: Ireland

AGENCY: United States NHLBI

GRANT: R01 HL054732-11

ACRONYM: HL

MEDLINETA: Mech Ageing Dev

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