Age-related alterations of Apolipoprotein E and interleukin-1beta in the aging brain.

Age-related alterations of Apolipoprotein E and interleukin-1beta in the aging brain. Research Abstract Details 

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Age-related alterations of Apolipoprotein E and interleukin-1beta in the aging brain. Abstract Text:

Jillian R Gee,Qunxing Ding,Jeffrey N Keller,

With normal aging, the brain undergoes several alterations including reduced neuronal functioning and alterations in glia homeostasis. An increase in inflammatory signaling has also been reported in some studies of the aging brain, with inflammation potentially mediating age-related changes in the brain. Apolipoprotein E (ApoE) is produced in the brain and has been shown to possess anti-inflammatory properties in a variety of paradigms. In the present study, we correlated age-related alterations in ApoE expression with age-related changes in the cytokine interleukin-1 beta (IL-1beta), in the brain of rats of increasing age. No significant alteration in ApoE mRNA was found in any region examined. A significant increase in IL-1beta mRNA with age was observed only in the cortex. Neither ApoE nor IL-1beta protein expression was significantly altered with age in the brain. A significant linear correlation between ApoE and IL-1beta mRNA was found in the cortex but not in the striatum or hippocampus. No correlation was found between ApoE and IL-1beta protein in any region examined. Taken together, these studies demonstrate that ApoE expression is not altered during normal brain aging, but suggest that there may be a relationship between ApoE and IL-1beta transcription in the cerebral cortex.

Age-related alterations of Apolipoprotein E and interleukin-1beta in the aging brain. Publishing Authors By Initials

JR Gee,Q Ding,JN Keller,

For similar animals: animal population groups: animals, inbred strains: rats, inbred strains: rats, inbred f344 research abstracts see: animals: animal population groups: animals, inbred strains: rats, inbred strains: rats, inbred f344 research

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Age-related alterations of Apolipoprotein E and interleukin-1beta in the aging brain. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Biogerontology

VOLUME: 7

Page Numbers: 69-79

Journal Abbreviation:

ISSN: 1389-5729

DAY: 3

MONTH: Apr

YEAR: 2006

Age-related alterations of Apolipoprotein E and interleukin-1beta in the aging brain. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 100930043

Age-related alterations of Apolipoprotein E and interleukin-1beta in the aging brain. Keywords Mesh Terms:

KEYWORDS: Rats, Inbred F344

MESH TERMS: metabolism

Chemical & Substance for Abstract: Age-related alterations of Apolipoprotein E and interleukin-1beta in the aging brain. Information

Substance Name: RNA, Messenger

Registry Number: 0

Grant and Affiliation Information for Age-related alterations of Apolipoprotein E and interleukin-1beta in the aging brain.

AFFILIATION: Department of Anatomy and Neurobiology, University of Kentucky, Lexington, KY 40536-0230, USA.

Country: Netherlands

AGENCY: United States NIA

GRANT: AG018437

ACRONYM: AG

MEDLINETA: Biogerontology

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