Age Modifies the Pituitary TSH Response to Thyroid Failure.

Age Modifies the Pituitary TSH Response to Thyroid Failure. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Age Modifies the Pituitary TSH Response to Thyroid Failure. Abstract Text:

Allan ,Peter Laurberg,Inge B Pedersen,Hans Perrild,Lars Ovesen,Lone B Rasmussen,Torben Jorgensen,Nils Knudsen,

Objective: To investigate the association between serum TSH, total T4 and various patient characteristics when hypothyroidism is diagnosed in a population, and to study how age, sex and serum T4 levels influenced pituitary TSH response. Design: A computer-based register linked to laboratory databases prospectively identified all patients with new, biochemically overt hypothyroidism (n = 685) in an open cohort in Denmark. The diagnosis was verified in each patient, and disease was classified into nosological type. Serum TSH and total T4 were recorded at the time of diagnosis in untreated patients with spontaneous autoimmune hypothyroidism (n = 578). Main outcome: In untreated primary, spontaneous autoimmune hypothyroidism, we observed a four fold difference in average serum TSH levels between the youngest (0-20 years: TSH = 100 mU/l) and the oldest (80+ years: TSH = 24.4 mU/l) group of patients. No age dependent variation was observed in serum total T4. Log TSH showed an inverse linear correlation with age. An inverse linear correlation was present between log TSH and total T4 in both young and old patients, but for all total T4 values we observed lower median serum TSH values in elderly patients. Conclusions: For the same degree of thyroid failure, the serum TSH is lower among the elderly. This is most likely caused by a decrease in the hypothalamic/pituitary response to low serum T4. A certain increase in serum TSH may indicate more severe hypothyroidism in an old than in a young patient, and longer time may be needed after thyroid hormone withdrawal before elderly patients with thyroid cancer reach sufficiently high TSH values to allow for an effective radio-iodine treatment.

Age Modifies the Pituitary TSH Response to Thyroid Failure. Publishing Authors By Initials

A ,P Laurberg,IB Pedersen,H Perrild,L Ovesen,LB Rasmussen,T Jorgensen,N Knudsen,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Age Modifies the Pituitary TSH Response to Thyroid Failure. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Thyroid : official journal of the American Thyroid

VOLUME: 17

Page Numbers: 139-44

Journal Abbreviation: Thyroid

ISSN: 1050-7256

DAY: 23

MONTH: Feb

YEAR: 2007

Age Modifies the Pituitary TSH Response to Thyroid Failure. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9104317

Age Modifies the Pituitary TSH Response to Thyroid Failure. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Age Modifies the Pituitary TSH Response to Thyroid Failure. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Age Modifies the Pituitary TSH Response to Thyroid Failure.

AFFILIATION: Department of Endocrinology and Medicine, Aalborg Hospital, Aarhus University Hospital, Denmark.

Country: United States

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Thyroid

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Age Modifies the Pituitary TSH Response to Thyroid Failure Related Publications

• Age Modifies the Pituitary TSH Response to Thyroid Failure.
• Bisphenol A facilitates bypass of androgen ablation therapy in prostate cancer.
• Discourses of agency and the search for the authentic self: The case of mood-modifying medicines.
• Gingival epithelial cells heterozygous for Toll-like receptor 4 polymorphisms Asp299Gly and Thr399ile are hypo-responsive to Porphyromonas gingivalis.
• Impact of differential cyclin D1 expression and localisation in prostate cancer.
• Improved parameter estimation for systems with an experimentally located Hopf bifurcation.
• Integrative database management for mouse development: systems and concepts.
• Loss of RB compromises specific heterochromatin modifications and modulates HP1alpha dynamics.
• Migrating with myosin VI.
• Mitogenic action of the androgen receptor sensitizes prostate cancer cells to taxane-based cytotoxic insult.
• Neuroimaging of the serotonin reuptake site requires high-affinity ligands.
• Patterns of organization and management in private and public substance abuse treatment programs.
• Phototoxic furanocoumarins.
• Placental perfusion - a human alternative.
• Psychiatry and torture.
• RB activity alters checkpoint response and chemosensitivity in lung cancer lines.
• RB loss abrogates cell cycle control and genome integrity to promote liver tumorigenesis.
• RB loss promotes aberrant ploidy by deregulating levels and activity of DNA replication factors.
• Regulation of cell proliferation in a stratified culture system of epithelial cells from prostate tissue.
• Regulation of global gene expression in the bone marrow microenvironment by androgen: androgen ablation increases insulin-like growth factor binding protein-5 expression.
• Reprogramming of genetic networks during initiation of the Fetal Alcohol Syndrome.
• Retinoblastoma tumor suppressor status is a critical determinant of therapeutic response in prostate cancer cells.
• SWI/SNF activity is required for the repression of deoxyribonucleotide triphosphate metabolic enzymes via the recruitment of mSin3B.
• Saint Lucia revisited.
• The human placenta - An alternative for studying foetal exposure.
• Tryptophane-205 of human topoisomerase I is essential for camptothecin inhibition of negative but not positive supercoil removal.
• Unique bisphenol A transcriptome in prostate cancer: novel effects on ERbeta expression that correspond to androgen receptor mutation status.
• Variability of estimated binding parameters.
• [Not Available.]
• [Not Available.]