Age-influenced population kinetics and immunological responses of Leishmania donovani in hamsters.

Age-influenced population kinetics and immunological responses of Leishmania donovani in hamsters. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Age-influenced population kinetics and immunological responses of Leishmania donovani in hamsters. Abstract Text:

Nasib Singh,Mukesh Samant,Shraddha K Gupta,Awanish Kumar,Anuradha Dube,Nasib Singh,Mukesh Samant,Shraddha K Gupta,Awanish Kumar,Anuradha Dube,Nasib Singh,Mukesh Samant,Shraddha K Gupta,Awanish Kumar,Anuradha Dube,

Susceptibility of animals to infections depends upon various factors including sex and age of the host, which plays a pivotal role. In this communication, we have investigated the "intake" of Leishmania donovani infection in young (3-4 weeks old) and adult (15-16 weeks old) golden hamsters. The splenic parasite load in young hamsters on day 15 post infection (p.i.) was 54 +/- 4 amastigotes/100 macrophage nuclei and increased to 106.3 +/- 3.5 on day 30 p.i. However, adult group showed 2.2-(P < 0.001) and 1.75-fold (P < 0.001) lesser parasite burden on these days, respectively. But as the disease progresses further, differences in parasite burden become less significant, as revealed by comparable levels of parasite loads at 2 months p.i. Spleen weight measurements correspond to the above observations. In the young group, the levels of antileishmanial antibody rise two and 4.5 times on days 15 and 30 p.i., respectively, as compared to only 1.3 and 2.3 times increase in their respective adult counterparts. However, after 2 months of infection both groups recorded analogous (12-fold) rise in antibody levels. Both mitogenic and antigenic responses in adult hamsters were less suppressed compared to young hamsters on days 15 and 30 p.i. However, both groups exhibited highly suppressed cell-mediated immune (CMI) responses after 2 months of infection. These findings implicate that age of the host may influence the susceptibility and resistance to Leishmania infection.

Age-influenced population kinetics and immunological responses of Leishmania donovani in hamsters. Publishing Authors By Initials

N Singh,M Samant,SK Gupta,A Kumar,A Dube,N Singh,M Samant,SK Gupta,A Kumar,A Dube,N Singh,M Samant,SK Gupta,A Kumar,A Dube,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Age-influenced population kinetics and immunological responses of Leishmania donovani in hamsters. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Parasitology research

VOLUME: 101

Page Numbers: 919-24

Journal Abbreviation: Parasitol. Res.

ISSN: 0932-0113

DAY: 7

MONTH: 05

YEAR: 2007

Age-influenced population kinetics and immunological responses of Leishmania donovani in hamsters. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8703571

Age-influenced population kinetics and immunological responses of Leishmania donovani in hamsters. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Age-influenced population kinetics and immunological responses of Leishmania donovani in hamsters. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Age-influenced population kinetics and immunological responses of Leishmania donovani in hamsters.

AFFILIATION: Division of Parasitology, Central Drug Research Institute, P.O. Box No. 173, Lucknow, 226 001, India, anuradha_dube@rediffmail.com.

Country: Germany

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Parasitol Res

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Age-influenced population kinetics and immunological responses of Leishmania donovani in hamsters Related Publications

• 5-Aminolevulinic acid-induced protoporphyrin-IX accumulation and associated phototoxicity in macrophages and oral cancer cell lines.
• A comparison of serum concentrations produced by phenethicillin, penicillin V, and penicillin G after oral and intramuscular administration in geriatric patients.
• A multitrophic approach to monitoring the effects of metal mining in otherwise pristine and ecologically sensitive rivers in northern Canada.
• A reduction of tropomyosin limits development of sarcomeric structures in cardiac mutant hearts of the mexican axolotl.
• Age-influenced population kinetics and immunological responses of Leishmania donovani in hamsters.
• An Age-Old Paradigm Challenged: Old Baboons Generate Vigorous Humoral Immune Responses to LcrV, A Plague Antigen.
• Can high-risk older drivers be identified through performance-based measures in a Department of Motor Vehicles setting?
• Complications after colorectal anastomosis in a patient with metastatic rectal cancer treated with systemic chemotherapy and bevacizumab.
• Evaluation of antileishmanial potential of Tinospora sinensis against experimental visceral leishmaniasis.
• Genetic analysis implicates resistin in HIV lipodystrophy.
• Hereditary multiple fibrofolliculomas with trichodiscomas and acrochordons.
• Improvement in HIV-related endothelial dysfunction using the anti-inflammatory agent salsalate: a pilot study.
• Increasing fathead minnow reproduction in an experimental setting: the effect of relative size on breeding potential.
• Induction of Th1-type cellular responses in cured/exposed Leishmania-infected patients and hamsters against polyproteins of soluble Leishmania donovani promastigotes ranging from 89.9 to 97.1kDa.
• Influence of stressful life events on the onset of Type 1 diabetes in childhood.
• Matching-to-sample assessment of stimulus overselectivity in students with intellectual disabilities.
• Neoadjuvant chemotherapy in invasive breast cancer results in a lower axillary lymph node count.
• Neuropeptide Y: potential role in recurrent developmental seizures.
• Overselective stimulus control in residential school students with intellectual disabilities.
• Review of the effects of in-stream pipeline crossing construction on aquatic ecosystems and examination of Canadian methodologies for impact assessment.
• Spatial memory of domestic dogs (Canis familiaris) for hidden objects in a detour task.
• Surgical margins in breast-conservation operations for invasive carcinoma: does neoadjuvant chemotherapy have an impact?
• Survey of foot pathology in an outpatient diabetic clinic.
• Two-stage strategies to detect gene x gene interactions in case-control data.
• Use of a differential observing response to expand restricted stimulus control.
• Weakened biological signals: Highly-developed eating schemas amongst women are associated with maladaptive patterns of comfort food consumption.
• Yersinia pestis CO92 delta yopH is a potent live, attenuated plague vaccine.
• [A provincial physician's interest in mineral waters and monsters in the 17th century.]
• [In Process Citation]
• [Not Available.]