Age effects on alpha-1-acid glycoprotein concentration and imipramine plasma protein binding.

Age effects on alpha-1-acid glycoprotein concentration and imipramine plasma protein binding. Research Abstract Details 

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Age effects on alpha-1-acid glycoprotein concentration and imipramine plasma protein binding. Abstract Text:

Alpha-1-acid glycoprotein concentration and imipramine binding to plasma proteins were determined in a cohort of 69 subjects, aged 20-97 years. No subject had evidence of acute or chronic inflammatory disease or malignancy, or was receiving tricyclic antidepressant therapy. Alpha-1-acid glycoprotein concentration increased significantly with increasing age (r = 0.28; P less than 0.02). Imipramine percentage not bound to plasma proteins was negatively related to alpha-1-acid glycoprotein concentration (r = -0.30; P less than 0.01); however, there was no relationship between subject age and percentage imipramine unbound. Though alpha-1-acid glycoprotein concentration increases with advancing age, because only a small proportion of the variability is explained by age, with other undefined factors being more important, drugs predominantly bound to alpha-1-acid glycoprotein such as imipramine may not have a clinically or statistically significant change in protein binding with increasing age in the absence of overt clinical illness.

Age effects on alpha-1-acid glycoprotein concentration and imipramine plasma protein binding. Publishing Authors By Initials

For similar biochemical phenomena, metabolism, and nutrition: biochemical phenomena: protein binding research abstracts see: biochemical phenomena, metabolism, and nutrition: biochemical phenomena: protein binding research

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Age effects on alpha-1-acid glycoprotein concentration and imipramine plasma protein binding. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Journal of the American Geriatrics Society

VOLUME: 32

Page Numbers: 705-8

Journal Abbreviation: J Am Geriatr Soc

ISSN: 0002-8614

DAY: 10

MONTH: Oct

YEAR: 1984

Age effects on alpha-1-acid glycoprotein concentration and imipramine plasma protein binding. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7503062

Age effects on alpha-1-acid glycoprotein concentration and imipramine plasma protein binding. Keywords Mesh Terms:

KEYWORDS: Protein Binding

MESH TERMS: metabolism

Chemical & Substance for Abstract: Age effects on alpha-1-acid glycoprotein concentration and imipramine plasma protein binding. Information

Substance Name: Imipramine

Registry Number: 50-49-7

Grant and Affiliation Information for Age effects on alpha-1-acid glycoprotein concentration and imipramine plasma protein binding.

AFFILIATION:

Country: UNITED STATES

AGENCY: United States NIADDK

GRANT: AM-32050

ACRONYM: AM

MEDLINETA: J Am Geriatr Soc

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