Age-dependent microdamage removal following mechanically induced microdamage in trabecular bone in vivo.

Age-dependent microdamage removal following mechanically induced microdamage in trabecular bone in vivo. Research Abstract Details 

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Age-dependent microdamage removal following mechanically induced microdamage in trabecular bone in vivo. Abstract Text:

Erik I Waldorff,Steven A Goldstein,Barbara R McCreadie,

In order to examine the potential age-related response of trabecular bone to microdamage, a novel animal model utilizing a bone chamber to load existing distal femoral trabecular bone of rats was developed. Fifteen 8-month-old (mature) and fifteen 24-month-old (old) Fischer Brown Norway rats underwent bilateral insertion of the bone chamber. After a 3-week recovery period, one leg per animal underwent damage-inducing loading. Double fluorochrome labeling was used to identify microcracks induced by loading. A greater crack density was found in loaded trabecular bone than in corresponding unloaded control bone at day 0 in both age groups (mature n=5, old n=4). At day 35 post loading, older rats (n=3) had greater crack density (suggesting little removal of microcracks), whereas younger rats (n=5) had no difference between loaded and unloaded limbs, suggesting induced microcracks were removed. The difference in bone volume fraction between the loaded and unloaded limb were significantly different at 21 and 35 days post loading when comparing the old with the mature rats. The data suggest a reduced ability of bone to recover after damage in the older rats. The damage-inducing capabilities of the animal model were demonstrated using double fluorochrome labeling in vivo for detection of microcracks. The results indicate that removal of microdamage is altered with age.

Age-dependent microdamage removal following mechanically induced microdamage in trabecular bone in vivo. Publishing Authors By Initials

EI Waldorff,SA Goldstein,BR McCreadie,

For similar animals: animal population groups: animals, inbred strains: rats, inbred strains: rats, inbred f344 research abstracts see: animals: animal population groups: animals, inbred strains: rats, inbred strains: rats, inbred f344 research

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Age-dependent microdamage removal following mechanically induced microdamage in trabecular bone in vivo. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Bone

VOLUME: 40

Page Numbers: 425-32

Journal Abbreviation: Bone

ISSN: 8756-3282

DAY: 19

MONTH: 10

YEAR: 2006

Age-dependent microdamage removal following mechanically induced microdamage in trabecular bone in vivo. Information

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LANGUAGE: eng

NlmUniqueID: 8504048

Age-dependent microdamage removal following mechanically induced microdamage in trabecular bone in vivo. Keywords Mesh Terms:

KEYWORDS: Rats, Inbred F344

MESH TERMS: pathology

Chemical & Substance for Abstract: Age-dependent microdamage removal following mechanically induced microdamage in trabecular bone in vivo. Information

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Grant and Affiliation Information for Age-dependent microdamage removal following mechanically induced microdamage in trabecular bone in vivo.

AFFILIATION: Orthopaedic Research Laboratories, Department of Orthopaedic Surgery, University of Michigan, BSRB Room 2003, 109 Zina Pitcher Place, Ann Arbor, MI 48109-2200, USA.

Country: United States

AGENCY: United States NIAMS

GRANT: AR46024

ACRONYM: AR

MEDLINETA: Bone

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