Age dependent increase in early resistance of mice to Mycobacterium tuberculosis is associated with an increase in CD8 T cells that are capable of antigen independent IFN-gamma production.

Age dependent increase in early resistance of mice to Mycobacterium tuberculosis is associated with an increase in CD8 T cells that are capable of antigen independent IFN-gamma production. Research Abstract Details 

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Age dependent increase in early resistance of mice to Mycobacterium tuberculosis is associated with an increase in CD8 T cells that are capable of antigen independent IFN-gamma production. Abstract Text:

Bridget Vesosky,David K Flaherty,Erin K Rottinghaus,Gillian L Beamer,Joanne Turner,

The lungs of naïve 18-month-old mice contain an abundant resident population of CD8 T cells that express typical markers of memory, express elevated levels of Th1 cytokine receptors on their surface, and are capable of non-specific IFN-gamma production in response to a Th1 cytokine cocktail. In this study we characterize this population of CD8 T cells in the lungs and spleens of mice with increasing age. In general, the proportion of CD8 T cells expressing markers of memory and Th1 cytokine receptors increased with age. The enhanced ability of CD8 T cells to produce IFN-gamma in an antigen independent manner followed this pattern as well, beginning to increase between 6 and 12 months of age. Interestingly, the phenotypic and functional age-related changes in CD8 T cells were also associated with a progressive age-related increase in early resistance to Mycobacterium tuberculosis. Taken together, these data suggest that as mice age a population of memory CD8 T cells, that are capable of contributing to innate immune responses to M. tuberculosis, gradually emerges and could be relevant for developing strategies to enhance immunity in the elderly.

Age dependent increase in early resistance of mice to Mycobacterium tuberculosis is associated with an increase in CD8 T cells that are capable of antigen independent IFN-gamma production. Publishing Authors By Initials

B Vesosky,DK Flaherty,EK Rottinghaus,GL Beamer,J Turner,

For similar bacterial infections and mycoses: bacterial infections: gram-positive bacterial infections: actinomycetales infections: mycobacterium infections: tuberculosis research abstracts see: bacterial infections and mycoses: bacterial infections: gram-positive bacterial infections: actinomycetales infections: mycobacterium infections: tuberculosis research

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Age dependent increase in early resistance of mice to Mycobacterium tuberculosis is associated with an increase in CD8 T cells that are capable of antigen independent IFN-gamma production. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Experimental gerontology

VOLUME: 41

Page Numbers: 1185-94

Journal Abbreviation: Exp. Gerontol.

ISSN: 0531-5565

DAY: 6

MONTH: 10

YEAR: 2006

Age dependent increase in early resistance of mice to Mycobacterium tuberculosis is associated with an increase in CD8 T cells that are capable of antigen independent IFN-gamma production. Information

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LANGUAGE: eng

NlmUniqueID: 47061

Age dependent increase in early resistance of mice to Mycobacterium tuberculosis is associated with an increase in CD8 T cells that are capable of antigen independent IFN-gamma production. Keywords Mesh Terms:

KEYWORDS: Tuberculosis

MESH TERMS: immunology

Chemical & Substance for Abstract: Age dependent increase in early resistance of mice to Mycobacterium tuberculosis is associated with an increase in CD8 T cells that are capable of antigen independent IFN-gamma production. Information

Substance Name: Interferon Type II

Registry Number: 82115-62-6

Grant and Affiliation Information for Age dependent increase in early resistance of mice to Mycobacterium tuberculosis is associated with an increase in CD8 T cells that are capable of antigen independent IFN-gamma production.

AFFILIATION: Center for Microbial Interface Biology, Division of Infectious Diseases, Department of Internal Medicine, The Ohio State University Columbus, OH 43210, USA. bridget.vesosky@osumc.edu

Country: England

AGENCY: United States NIA

GRANT: R01 AG21097

ACRONYM: AG

MEDLINETA: Exp Gerontol

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