Age-dependent differences in IgG isotype and avidity induced by measles vaccine received during the first year of life.

Age-dependent differences in IgG isotype and avidity induced by measles vaccine received during the first year of life. Research Abstract Details 

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Age-dependent differences in IgG isotype and avidity induced by measles vaccine received during the first year of life. Abstract Text:

Nitya Nair,Hayley Gans,Linda Lew-Yasukawa,Andrea C Long-Wagar,Ann Arvin,Diane E Griffin,Nitya Nair,Hayley Gans,Linda Lew-Yasukawa,Andrea C Long-Wagar,Ann Arvin,Diane E Griffin,Nitya Nair,Hayley Gans,Linda Lew-Yasukawa,Andrea C Long-Wagar,Ann Arvin,Diane E Griffin,

BACKGROUND: Measles remains an important cause of death worldwide, and vaccinating individuals at an earlier age could lead to better control of the disease. However, persistence of maternal antibody and young age affect the quantity of vaccine-induced neutralizing antibody and may also affect antibody quality. METHODS: Enzyme immunoassay was used to analyze measles virus-specific IgG levels, avidity maturation, and isotype changes, using serum samples from infants who received measles vaccine at 6 months of age and measles-mumps-rubella (MMR)-II at 12 months of age (n=26), measles vaccine at 9 months of age and measles-mumps-rubella (MMR)-II at 12 months of age (n=48), or only MMR-II at 12 months of age (n=27). RESULTS: The median IgG level was lower among infants with maternal antibody than among those without maternal antibody. Compared with median avidity indices for infants aged 12 months, median values were lower for 6-month-old infants with maternal antibody (P=.0001), 6-month-old infants without maternal antibody (P=.001), 9-month-old infants with maternal antibody (P=.03), and 9-month-old infants without maternal antibody (P=.006). The median IgG3 level was highest at 6 months of age. IgG1 was predominant at 12 months. Low avidity responses at 6 or 9 months of age did not hinder higher avidity responses or the switch to IgG1 after secondary vaccination. The 2-dose regimen did not augment the response, compared with the response in infants who received 1 dose at 12 months of age. CONCLUSIONS: Avidity and isotype maturation of measles vaccine-induced antibody are affected by age, providing insight into the ontogeny of the immune response to measles vaccine.

Age-dependent differences in IgG isotype and avidity induced by measles vaccine received during the first year of life. Publishing Authors By Initials

N Nair,H Gans,L Lew-Yasukawa,AC Long-Wagar,A Arvin,DE Griffin,N Nair,H Gans,L Lew-Yasukawa,AC Long-Wagar,A Arvin,DE Griffin,N Nair,H Gans,L Lew-Yasukawa,AC Long-Wagar,A Arvin,DE Griffin,

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Age-dependent differences in IgG isotype and avidity induced by measles vaccine received during the first year of life. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: The Journal of infectious diseases

VOLUME: 196

Page Numbers: 1339-45

Journal Abbreviation: J. Infect. Dis.

ISSN: 0022-1899

DAY: 2

MONTH: 10

YEAR: 2007

Age-dependent differences in IgG isotype and avidity induced by measles vaccine received during the first year of life. Information

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LANGUAGE: eng

NlmUniqueID: 413675

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Grant and Affiliation Information for Age-dependent differences in IgG isotype and avidity induced by measles vaccine received during the first year of life.

AFFILIATION: W Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA.

Country: United States

AGENCY: United States NIAID

GRANT: R01 AI23047

ACRONYM: AI

MEDLINETA: J Infect Dis

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