Age-dependent differences in human brain activity using a face- and location-matching task: an FMRI study.

Age-dependent differences in human brain activity using a face- and location-matching task: an FMRI study. Research Abstract Details 

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Age-dependent differences in human brain activity using a face- and location-matching task: an FMRI study. Abstract Text:

G Leinsinger,C Born,T Meindl,A L W Bokde,S Britsch,P Lopez-Bayo,S J Teipel,H-J Moller,H Hampel,M F Reiser,G Leinsinger,C Born,T Meindl,A L W Bokde,S Britsch,P Lopez-Bayo,S J Teipel,H-J Moller,H Hampel,M F Reiser,

PURPOSE: To evaluate the differences of cortical activation patterns in young and elderly healthy subjects for object and spatial visual processing using a face- and location-matching task. MATERIALS AND METHODS: We performed a face- and a location-matching task in 15 young (mean age: 28 +/- 9 years) and 19 elderly (mean age: 71 +/- 6 years) subjects. Each experiment consisted of 7 blocks alternating between activation and control condition. For face matching, the subjects had to indicate whether two displayed faces were identical or different. For location matching, the subjects had to press a button whenever two objects had an identical position. For control condition, we used a perception task with abstract images. Functional imaging was performed on a 1.5-tesla scanner using an EPI sequence. RESULTS: In the face-matching task, the young subjects showed bilateral (right > left) activation in the occipito-temporal pathway (occipital gyrus, inferior and middle temporal gyrus). Predominantly right hemispheric activations were found in the fusiform gyrus, the right dorsolateral prefrontal cortex (inferior and middle frontal gyrus) and the superior parietal gyrus. In the elderly subjects, the activated areas in the right fronto-lateral cortex increased. An additional activated area could be found in the medial frontal gyrus (right > left). In the location-matching task, young subjects presented increased bilateral (right > left) activation in the superior parietal lobe and precuneus compared with face matching. The activations in the occipito-temporal pathway, in the right fronto-lateral cortex and the fusiform gyrus were similar to the activations found in the face-matching task. In the elderly subjects, we detected similar activation patterns compared to the young subjects with additional activations in the medial frontal gyrus. CONCLUSION: Activation patterns for object-based and spatial visual processing were established in the young and elderly healthy subjects. Differences between the elderly and young subjects could be evaluated, especially by using a face-matching task.

Age-dependent differences in human brain activity using a face- and location-matching task: an FMRI study. Publishing Authors By Initials

G Leinsinger,C Born,T Meindl,AL Bokde,S Britsch,P Lopez-Bayo,SJ Teipel,HJ Moller,H Hampel,MF Reiser,G Leinsinger,C Born,T Meindl,AL Bokde,S Britsch,P Lopez-Bayo,SJ Teipel,HJ Moller,H Hampel,MF Reiser,

For similar psychological phenomena and processes: mental processes: perception: space perception research abstracts see: psychological phenomena and processes: mental processes: perception: space perception research

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Age-dependent differences in human brain activity using a face- and location-matching task: an FMRI study. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Dementia and geriatric cognitive disorders

VOLUME: 24

Page Numbers: 235-46

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ISSN: 1420-8008

DAY: 14

MONTH: 08

YEAR: 2007

Age-dependent differences in human brain activity using a face- and location-matching task: an FMRI study. Information

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LANGUAGE: eng

NlmUniqueID: 9705200

Age-dependent differences in human brain activity using a face- and location-matching task: an FMRI study. Keywords Mesh Terms:

KEYWORDS: Space Perception

MESH TERMS: physiology

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Grant and Affiliation Information for Age-dependent differences in human brain activity using a face- and location-matching task: an FMRI study.

AFFILIATION: Department for Clinical Radiology, Alzheimer Memorial Center and Geriatric Psychiatry Branch, Munich, Germany.

Country: Switzerland

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MEDLINETA: Dement Geriatr Cogn Disord

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